摘要
目的提醒临床医生在使用抗菌药物时应密切关注用药安全。方法分析1例45岁男性患者先后静脉滴注哌拉西林他唑巴坦、亚胺培南西司他丁、左氧氟沙星后出现中毒性表皮坏死松解症(TEN)的病例资料,文献回顾TEN的发病机制和治疗措施。结果该患者由哌拉西林他唑巴坦、亚胺培南西司他丁、左氧氟沙星引起TEN的可能性大,经过及时停药,积极抗过敏、系统免疫治疗及对症支持治疗后,患者皮肤症状逐渐缓解。结论哌拉西林他唑巴坦、亚胺培南西司他丁、左氧氟沙星致TEN的发生率低,但病死率高,预后差,应引起临床重视。
Objective To remind the medical staff to pay close attention to medication safety of antibacterial drugs. Methods One case of toxic epidermal necrolysis(TEN) after intravenous infusion of piperacillin tazobactam, imipenem/cilastatin, and levofloxacin in a 45-year-old male patient was analyzed while literature about the pathogenesis and treatment of TEN was reviewed. Results Toxic epidermal necrolysis was most likely to be induced by piperacillin tazobactam, imipenem/cilastatin, and levofloxacin in this patient. The symptoms on the patient’s skin were relieved gradually via timely discontinuation of the drugs, anti-allergic therapy, systemic immunotherapy, and symptomatic supportive treatment. Conclusion Toxic epidermal necrolysis induced by piperacillin tazobactam, imipenem/cilastatin, and levofloxacin is a disease with low incidence, but with a high mortality and poor prognosis, which deserves attention.
作者
罗晓枫
杜倩
奚鑫
冉海龙
LUO Xiaofeng;DU Qian;XI Xin;RAN Hailong(School of Pharmacy,Chongqing Medical University,Chongqing 400016,China;Department of Pharmacy,the Third Affiliated Hospital of Chongqing Medical University(Gener Hospital),Chongqing 401120,China)
出处
《中国药物警戒》
2020年第8期535-538,共4页
Chinese Journal of Pharmacovigilance
