摘要
目的调查大连地区人群非典型趋化因子受体1多态性与丙型肝炎病毒(HCV)易感性的相关性。方法选取2015年4月至2015年12月就诊于大连市传染病医院的231例抗-HCV及丙型肝炎病毒核酸(HCV-RNA)阳性的HCV感染者作为观察组,选取同期239名无血缘关系的健康献血者作为对照组。使用TaqMan-MGB探针实时定量PCR技术对两组样本进行非典型趋化因子受体1基因分型。结果两组FY*A/FY*A、FY*B/FY*B和FY*A/FY*B的基因型分布与FY*A、FY*B的等位基因分布未发现显著差异。结论非典型趋化因子受体1的多态性不能直接影响HCV的易感性。
Objective To investigate the relationship between Atypical Chemokine Receptor 1 polymorphism and the susceptibility to hepatitis C virus(HCV)in Dalian Region.Methods From April 2015 to December 2015,a total of 231 patients with HCV infection at Dalian Infectious Hospital were recruited to participate in this study as observation group,and 239 unrelated healthy blood donors were recruited for the control group.The samples were genotyped by TaqMan minor groove binding probes on a real-time PCR platform.Results The genotype distribution of FY*A/FY*A、FY*B/FY*B and FY*A/FY*B and the allele distribution of FY*A and FY*B between HCV-infected patients and control group were not significant.Conclusion Atypical Chemokine Receptor 1 polymorphism(rs12075)does not affect susceptibility to HCV.
作者
张树婷
邵林楠
周世航
王霓
肖南
刘铭
ZHANG Shuting;SHAO Linnan;ZHOU Shihang;WANG Ni;XIAO Nan;LIU Ming(Department of Blood Group,Dalian Blood Center,Dalian 116001,China;Department of Cell Biology,Dalian Medical University,Dalian 116044,China)
出处
《中国医药指南》
2020年第22期39-40,共2页
Guide of China Medicine
基金
大连市青年科技之星项目(2017RQ170)。
