摘要
目的探讨红花注射液治疗活动期类风湿关节炎的临床效果以及对纤维蛋白原和D-二聚体表达的影响。方法选取2018年1月—2018年12月收治的活动期类风湿关节炎80例,按照数字表法随机分成对照组和观察组,每组40例。对照组予以西药口服,对观察组在予以西药口服基础上联合予以红花注射液静脉滴注治疗。干预治疗后2周后,分别对两组的关节压痛情况、疾病活动度、炎症水平、凝血功能以及治疗有效率进行比较。结果①观察组的疼痛视觉模拟评分(Visual Analogue Scale,VAS)、疾病活动性评分(Disease Activity Score-28,DAS28)评分均显著低于对照组,差异有统计学意义(P<0.05);②观察组的C反应蛋白(C Reactive Protein,CRP)、血沉(Erythrocyte Sedimentation Rate,ESR)以及白细胞介素-1(Interleulin-1,IL-1)水平显著低于对照组,差异有统计学意义(P<0.05);③观察组的纤维蛋白原(Fibrinogen,FIB)、D-二聚体(D-Dimer,D-D)水平显著低于对照组,差异有统计学意义(P<0.05);④观察组的总治疗有效率为97.50%(39/40),显著高于对照组的总治疗有效率80.00%(32/40)(P<0.05)。结论采用红花注射液对类风湿关节炎患者进行治疗,能够有效改善活动期类风湿关节炎患者的炎症水平以及凝血功能,缓解关节疼痛,取得较好的临床治疗效果。
Objective To explore the effect of Safflower Injection on the expressions of fibrinogen and D-dimer in active rheumatoid arthritis.Methods Eighty patients with active rheumatoid arthritis in our hospital from January 2018 to December 2018 were randomly divided into control group and observation group,40 cases in each group.Patients in the control group were treated with routine western medicine,while patients in the observation group were treated with Safflower Injection intravenously on the basis of routine western medicine.Two weeks after the intervention,the joint tenderness,disease activity,inflammation level,coagulation function and treatment efficiency were compared between the two groups.Results①Visual analogue scale(VAS)and disease activity score-28(DAS28)scores in the observation group were significantly lower than those in the control group(P<0.05).②The levels of C reactive protein(CRP),erythrocyte sedimentation rate(ESR)and interleulin-1(IL-1)in the observation group were lower than those of the control group(P<0.05).③The levels of fibrinogen(FIB)and D-dimer(D-D)in the observation group were lower than those of the control group(P<0.05).④The total effective rate of the observation group was 97.50%(39/40),which was significantly higher than that of the control group(80.00%,32/40)(P<0.05).Conclusion Using Safflower Injection to treat patients with rheumatoid arthritis can effectively relieve inflammation and improve coagulation function of patients with active rheumatoid arthritis,alleviate joint pain and achieve better clinical therapeutic effect.
作者
任占芬
杨金良
罗寰
白晓敏
REN Zhanfen;YANG Jinliang;LUO Huan;BAI Xiaomin(Department of Rheumatology and Immunology,The First Affiliated Hospital of Hebei North University,Shijiazhuang 075000,Hebei,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第6期225-228,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河北省卫生厅科研基金(20170821)。
