摘要
目的观察复方磺胺甲噁唑片联合替加环素治疗慢性阻塞性肺疾病(COPD)患者多重耐药菌感染的临床疗效。方法多重耐药菌感染的COPD患者175例分为两组。对照组90例,予替加环素50 mg静脉滴注,每12小时1次;观察组85例,加用复方磺胺甲噁唑片2片口服,每日2次。两组均治疗14 d,比较两组治疗前后炎症指标、动脉血气指标、临床总有效率、细菌清除率及再感染率等。结果两组治疗后,炎症指标均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后动脉血气指标均较治疗前改善(P<0.05),且观察组HCO3-低于对照组(P<0.05)。观察组临床总有效率和细菌清除率均高于对照组(P<0.05),而体温恢复时间、住院费用、随访1个月后死亡率均低于对照组(P<0.05)。结论复方磺胺甲噁唑片联合替加环素治疗COPD患者多重耐药菌感染疗效较替加环素单用显著。
Objective To observe the efficacy of compound sulfamethoxazole tablets combined with tigecycline in treating multi-drug resistant bacterial infections in the patients with chronic obstructive pulmonary disease(COPD).Methods A total of 175 COPD patients with multi-drug resistant bacterial infections was divided into two groups.Tigecycline 50 mg was given intravenously once every 12 hours for 14 days in 90 cases(group C).The patients in group A(85 cases) were additionally treated with compound sulfamethoxazole tablets orally 2 tablets twice a day for 14 days.The inflammation indicators and arterial blood gas analysis were detected before and after treatment.The clinical total effective rate and reinfection rate were compared between the two groups.ResultsThe inflammation indicators after treatment in both groups were lower than those before(P<0.05),which in group A were lower than those in group C(P<0.05).Compared with before treatment,arterial blood gas analysis after treatment in both groups was improved(P<0.05),in which HCO3- after treatment was lower in group A than that in group C(P<0.05).The total clinical effective rate and bacterial clearance rate in group A were higher than those in group C(P<0.05),while the time for temperature recovery,hospitalization costs and one-month mortality were lower in group A than those in group C(P<0.05).Conclusion Combined use of compound sulfamethoxazole tablets and tigecycline has better efficacy than tigecycline alone in the treatment of COPD patients with multi-drug resistant bacterial infections.
作者
傅裕民
陈晨
赵继京
邹丽珍
张伟星
王绍斌
FU Yumin;CHEN Chen;ZHAO Jijing(Department of Respiratory Diseases,Second Affiliated Hospital(Jiande Branch),School of Medicine,Zhejiang University,Jiande 311600,CHINA)
出处
《江苏医药》
CAS
2020年第6期623-626,共4页
Jiangsu Medical Journal
关键词
慢性阻塞性肺疾病
复方磺胺甲噁唑片
替加环素
多重耐药菌
Chronic obstructive pulmonary disease
Compound sulfamethoxazole tablets
Tigecycline
Multi-drug resistant bacteria
