摘要
目的探讨孕早期抗梅毒治疗对妊娠期梅毒孕妇妊娠结局及新生儿预后的影响。方法选取2016年6月至2018年6月深圳市龙华区人民医院诊治的妊娠期梅毒孕妇150例作为研究对象。根据抗梅毒治疗时机不同分为观察组(n=75)、对照组(n=75),两组均予以苄星青霉素治疗,观察组孕早期(孕周<13周)行抗梅毒治疗,对照组孕中晚期(孕周≥13周)行抗梅毒治疗,对两组孕妇妊娠结局、新生儿娩出时情况、新生儿预后情况、不同RPR滴度下新生儿梅毒感染情况进行观察。结果不良妊娠结局发生率观察组为6.67%,低于对照组(17.33%),差异具有统计学意义(P<0.05);观察组新生儿Apgar评分及出生体重均高于对照组,差异具有统计学意义(P<0.05),两组呼吸和心率比较,差异无统计学意义(P>0.05);观察组低体重儿、新生儿死亡、新生儿窒息、新生儿梅毒感染占比与对照组比均较低,差异具有统计学意义(P<0.05);两组孕妇RPR滴度≤1∶8时,新生儿梅毒感染率差异无统计学意义(P>0.05),当孕妇RPR滴度>1∶8时,观察组新生儿梅毒感染率低于对照组且差异具有统计学意义(P<0.05)。结论孕早期抗梅毒治疗可减少妊娠期梅毒孕妇不良妊娠结局,阻断梅毒垂直传播,改善新生儿预后,值得推广。
Objective To probe into the influence of antisyphilis treatment in early pregnancy on the pregnancy outcome and neonatal prognosis of pregnant women with syphilis.Methods 150 pregnant women with syphilis in Shenzhen Longhua District People's Hospital from June 2016 to June 2018 were included and divided into the observation group(75 cases)and the control group(75 cases)according to the timing of anti-syphilis treatment.All the pregnant women in the two groups were treated with benzathine penicillin.The observation group received anti-syphilis treatment in early pregnancy(gestational week<13 weeks),while the control group received anti-syphilis treatment in the second and third trimesters of pregnancy(gestational weeks≥13 weeks).The pregnancy outcome,neonatal delivery outcome,neonatal prognosis,neonatal syphilis infection under different RPR titers in the two groups were observed.Results The incidence of adverse pregnancy outcomes in the observation group(6.67%)was lower than that in the control group(17.33%),with statistically significant differences(P<0.05).The Apgar scores and body weight of newborns in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in respiratory rate and heart rate between the two groups(P>0.05).The proportion of low birth weight infants,neonatal death,neonatal asphyxia and neonatal syphilis infection in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).There was no significant difference in syphilis infection rate between the two groups when RPR titer≤1∶8(P>0.05).When RPR titer of pregnant women>1∶8,the neonatal syphilis infection rate in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).Conclusions The antisyphilis treatment in early pregnancy can reduce the adverse pregnancy outcomes of pregnant women with syphilis,block the vertical transmission of syphilis and improve the prognosis of newborns,which is worth promoting.
作者
廖湘竹
钟雪莉
吴轶西
罗丽琼
LIAO Xiangzhu;ZHONG Xueli;WU Yixi;LUO Liqiong(Department of Obstetrics,Shenzhen Longhua District People's Hospital,Shenzhen 518000,Guangdong,China;Department of Dermatology,Shenzhen Longhua District People's Hospital,Shenzhen 518000,Guangdong,China)
出处
《中国性科学》
2020年第6期116-119,共4页
Chinese Journal of Human Sexuality
关键词
抗梅毒治疗时机
苄星青霉素
妊娠期
妊娠结局
新生儿预后
Timing of antisyphilis treatment
Benzathine penicillin
Pregnancy
Pregnancy outcome
Neonatal prognosis
