摘要
目的探讨四肢脂肪肉瘤患者的临床病理特征、诊断及鉴别诊断。方法选取2002年3月至2019年12月首都医科大学附属北京天坛医院收治的非典型脂肪瘤性肿瘤/高分化脂肪肉瘤(ALT/WDL)、去分化脂肪肉瘤(DDL)、黏液样脂肪肉瘤(ML)患者共14例,采用荧光原位杂交(FISH)和免疫组织化学染色法检测肿瘤组织中MDM2基因扩增和S-100、CDK4、MDM2蛋白表达,结合临床资料和病理组织学特点综合分析不同类型脂肪肉瘤的特点。结果14例患者年龄(55.6±16.7)岁,男性10例,女性4例。ALT/WDL为2例,DDL为6例,ML为6例。免疫组织化学结果显示,所有患者S-100均有表达,包括散在阳性、部分阳性及广泛阳性;CDK4、MDM2在ALT/WDL和DDL中均有表达,在ML中弱表达(4例);所有患者Vimentin均表达。2例ALT/WDL和6例DDL均检测到MDM2基因扩增。结论脂肪肉瘤发病率高,具有明显的形态多样性,准确的病理诊断是判断肿瘤预后和治疗的关键。
Objective To investigate the clinicopathological characteristics,diagnosis and differential diagnosis of liposarcoma of the extremities.Methods Fourteen patients with atypical lipomatous tumor/well-differentiated liposarcoma(ALT/WDL),dedifferentiated liposarcoma(DDL)and myxoid liposarcoma(ML)in Beijing Tiantan Hospital of Capital Medical University from March 2002 to December 2019 were collected.Fluorescence in situ hybridization(FISH)and immunohistochemical staining were used to detect the MDM2 gene amplification and expressions of S-100,CDK4 and MDM2 proteins in tumor tissues.The characteristics of different types of liposarcoma were comprehensively analyzed combined with clinical data and histopathological characteristics.Results The age of 14 patients was(55.6±16.7)years old,with 10 males and 4 females.There were 2 cases of ALT/WDL,6 cases of DDL,and 6 cases of ML.Immunohistochemistry showed that S-100 was positive in all patients and the patterns were scattered,partial and extensive.CDK4 and MDM2 were positive in both ALT/WDL and DDL,and weakly expressed in ML(4 cases).Vimentin was positive in all patients.MDM2 gene amplification was detected in 2 cases of ALT/WDL and 6 cases of DDL.Conclusion Liposarcoma has a high incidence and obvious morphological diversity,accurate diagnosis is critical to the prognosis and treatment of the tumor.
作者
李雪
武迎
李少祥
李振强
边宇
关春燕
高子芬
董格红
Li Xue;Wu Ying;Li Shaoxiang;Li Zhenqiang;Bian Yu;Guan Chunyan;Gao Zifen;Dong Gehong(Department of Pathology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《肿瘤研究与临床》
CAS
2020年第6期405-409,共5页
Cancer Research and Clinic
关键词
脂肪肉瘤
四肢
诊断
诊断
鉴别
Liposarcoma
Extremities
Diagnosis
Diagnosis,differential
