摘要
目的:探讨结直肠癌患者术后C反应蛋白/血清白蛋白比值(CAR)对结直肠癌患者术后发生早期吻合口漏的预测价值。方法:对2016年9月至2019年9月期间就诊于本院胃肠外科的结直肠癌患者进行回顾性分析,包括患者的基线资料,术后第1、3、5、7天C反应蛋白(CRP)、降钙素原(PCT)和血清白蛋白(ALB)水平。根据术后7 d内是否有吻合口漏分为吻合口漏组和无吻合口漏组,并对两组相关数据进行统计分析。结果:吻合口漏组和无吻合口漏组患者的年龄、BMI、手术时间、术中出血量等基线数据差异均无统计学意义(P>0.05);但吻合口漏组的住院时间长于非吻合口漏组(P<0.05)。吻合口漏组术后第3天CRP水平、第5天PCT水平均高于非吻合口漏组(P<0.05)。吻合口漏组术后第3天和第5天的CAR值均高于非吻合口漏组(P<0.05),术后第3天的CAR值(2.30)预测结直肠癌术后早期吻合口漏的灵敏度为79.23%,特异度为87.45%,优于单纯使用CRP和(或)PCT。结论:术后CAR对结直肠癌术后患者早期吻合口漏发生有较好的预测能力。
Objective To explore the relationship between the level of C-reactive protein/serum albumin ratio(CAR)and early postoperative anastomotic leakage in patients with colorectal cancer.Methods From September 2016 to September 2019,all colorectal cancer patients who were treated in gastrointestinal surgery of Jinjiang hospital in Fujian Province were collected for retrospective analysis.The baseline data of the patients were collected.The blood C-reactive protein(CRP),procalcitonin(PCT)and serum albumin(ALB)were monitored on the first,third,fifth and seventh days after operation,and the results were statistically analyzed.Results There was no significant difference in baseline data such as age,body mass index(BMI),operation time and intraoperative hemorrhage between the anastomotic leakage group and the non anastomotic leakage group(P>0.05),but the hospitalization time of the anastomotic leakage group was longer than that of the non anastomotic leakage group(P<0.05).The CRP level on the 3rd and PCT level on the 5th day after operation in the anastomotic leakage group were higher than those in the non anastomotic leakage group,with significant difference(P<0.05).The CAR value on the 3rd and 5th day after operation in the anastomotic leakage group was higher than those in the non anastomotic leakage group with significant difference(P<0.05).Conclusions CAR can predict early anastomotic leakage in patients with colorectal cancer.
作者
许国玺
林高枫
王怀帅
庄奕翔
李银林
林奇忆
蔡志聪
刘维波
叶再元
Xu Guoxi;Lin Gaofeng;Wang Huaishuai;Zhuang Yixiang;Li Yinlin;Lin Qiyi;Cai Zhicong;Liu Weibo;Ye Zaiyuan(Department of Gastroenterology,Jinjiang Hospital,Jinjiang 362200,China;Department of Gastrointestinal Surgery,Shulan(Hangzhou)Hospital,Hangzhou 330022,China)
出处
《中国医师杂志》
CAS
2020年第6期818-821,共4页
Journal of Chinese Physician
