摘要
肿瘤患者营养不良的发生率很高,营养不良降低患者临床疗效和生存率并影响患者的生活质量,因此,在很大程度上引起临床医师的关注。营养不良与肿瘤转移之间相互影响、相互促进,肿瘤患者营养不良发生率越高,肿瘤浸润和转移率越高,营养不良程度越重,浸润和转移程度越重,同时随着肿瘤的转移,患者营养不良的发生率也增大,最终使患者病死率增加。肿瘤患者营养不良根本原因是营养摄入减少和消耗增加。瘤体本身导致的各种并发症,肿瘤造成的代谢紊乱,瘤细胞分泌的多种炎症因子,在治疗过程中会发生各种不良反应和手术并发症及患者焦虑、抑郁的心理因素都与患者营养不良有关。而营养不良促进肿瘤转移,其具体机制可能与肿瘤患者存在的免疫功能受损、炎性反应、瘦素水平下降、血管生成素样蛋白、肿瘤细胞自噬等有关。对患者营养不良的治疗可降低肿瘤转移的风险,防止肿瘤转移可提高患者的营养状态,而对肿瘤患者营养不良和浸润转移相关机制的研究,可为肿瘤治疗提供新的方向。
The incidence of malnutrition in cancer patients is very high.Malnutrition will reduce the clinical efficacy,survival rate,and affect the quality of life of patients.Malnutrition and tumor metastasis interact and promote each other,which are the higher the incidence of malnutrition,the higher the rate of tumor infiltration and metastasis,the more severe the degree of malnutrition infiltration and metastasis.At the same time,with the metastasis of tumors,the incidence of malnutrition in patients also increases,ultimately,increasing the mortality rate of patients.The underlying cause of malnutrition in cancer patients is reduced nutrient intake and increased consumption.Various complications caused by the tumor itself,metabolic disorders caused by the tumor,various inflammatory factors secreted by the tumor cells,various adverse reactions and surgical complications during the treatment,and psychological factors of anxiety and depression of patients are all related to malnutrition.Malnutrition promotes tumor metastasis,and its specific mechanism may be related to the impaired immune function,inflammatory response,decreased leptin level,angiopoietin-like protein,autophagy of tumor cells,and so on.The treatment of malnutrition in patients can reduce the risk of tumor metastasis and prevent tumor metastasis can improve the nutritional status of patients.The study of the mechanisms related to malnutrition and infiltration and metastasis in cancer patients can provide a new direction for tumor treatment.
作者
刘乾
尹振宇
屈才浩
李雪梅
李晓梅
齐文博
刘乐
白玉萍
陈昊
Liu Qian;Yin Zhenyu;Qu Caihao;Li Xuemei;Li Xiaomei;Qi Wenbo;Liu Le;Bai Yuping;Chen Hao(The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;the Department of Tumor Surgery,Lanzhou University Second Hospital,Lanzhou 730000,Gansu,China;The Key Laboratory of the Digestive System Tumors of Gansu Province,Lanzhou 730000,Gansu,China)
出处
《肿瘤代谢与营养电子杂志》
2020年第2期240-244,共5页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
国家自然科学基金项目(81670594,81470791,81376597)
甘肃省重点人才项目(甘肃省省委组织部)
甘肃省基础研究创新群体项目(1606RJIA328)
甘肃省卫生行业科研计划项目(GSWSKY2017-09)
兰州市人才创新创业项目(2017-RC-62)
甘肃省科技重大专项(19ZD2WA001)。
关键词
肿瘤
转移
营养不良
Tumor
Metastasis
Malnutrition
