摘要
放射性肠炎(RE)是腹盆腔或腹膜后恶性肿瘤放射治疗导致的肠道最严重、最常见并发症之一。受累肠道病变广泛、复杂、迁延不愈,治疗难度极大,效果欠佳,严重者可形成短肠综合征。作为人体最大、最复杂的微生态系统,肠道菌群功能十分广泛。研究表明,肠道菌群在放射所导致的RE发病中起重要作用。本文总结了RE和肠道菌群的相关性及最新研究进展。
Radioactive enteritis(RE)is one of the most serious and common complications of intestinal tract caused by radiotherapy for malignant tumors in abdominal cavity,pelvic cavity,or retroperitoneum.Involved intestinal diseases are widespread,complex,and persistent,which make treatment difficult and ineffective.Short bowel syndrome can develop in some serious cases.Gut flora is the largest and most complex micro-ecosystem in human body and has a wide range of functions.Studies have shown that intestinal flora plays an important role in radiation-induced RE.This article summarizes recent research advances in the relationship between RE and gut flora.
作者
朱长真
李元新
ZHU Changzhen;LI Yuanxin(Department of Gastrointestinal Surgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2020年第3期405-409,共5页
Acta Academiae Medicinae Sinicae
关键词
放射性肠炎
肠道微生态
益生菌
放射性损伤
radiation enteritis
gut microecology
probiotics
radiation injury
