期刊文献+

急性脑梗死溶栓治疗预后影响因素分析 被引量:2

在线阅读 下载PDF
导出
摘要 目的:探析经溶栓治疗,急性脑梗死患者的近期与远期预后影响因素,为今后的临床治疗提供可靠的治疗依据。方法:观察对象来自我院2009年6月至2014年12月收治的急性脑梗死患者129例,使用重组织型纤溶酶原激活剂(rt-PA)接受溶栓治疗,对患者24h与3个月后疗效进行评估,并分析预后影响因素。结果:129例患者经溶栓治疗,24h病情得以好转患者56例,约占总数43.4%,多因素Logistic回归分析,未发现以上因素与近期(24h)疗效有关;随访患者3个月,有效患者共115例,接受溶栓治疗后mRS评分在0~1分患者共51例,约占总数44.3%,多因素Logistic回归分析,发现吸烟史、胆固醇、LDL-C、THRIVE评分、溶栓前NIHSS评分、发病至溶栓间隔时间、载脂蛋白B、近期预后各因素与远期预后存在密切关联。结论:急性脑梗死患者经溶栓治疗,24h症状改善效果明显患者,其远期(3个月)疗效佳,但存在高血压与房颤史患者,其近期(24h)疗效难以达到理想效果;溶栓治疗急性脑梗死患者时,对于那些存在房颤史、脂蛋白a含量低、治疗前NIHSS评分高、HDL-C含量高患者,需做好溶栓后继发性HT的预防工作。
出处 《医学食疗与健康》 2020年第14期81-82,共2页 Medical Diet and Health
  • 相关文献

参考文献5

二级参考文献50

  • 1No authors listed, lntracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group [J]. Stroke, 1997, 28(11): 2109-2118.
  • 2Reeves M, Bhatt A, Jajou P, et al. Sex differences in the use of intravenous rt-PA thrombolysis treatment for acute ischemic stroke: a meta-analysis[J]. Stroke, 2009, 40(5): 1743-1749.
  • 3De Silva DA, Ebinger M, Davis SM. Gender issues in acute stroke thrombolysis[J]. J Clin Neurosci, 2009, 16(4): 501-504.
  • 4Jovanovic DR, Beslac-Bumbasirevic Lj, Budimkic M, et al. Do women benefit more from systemic thrombolysis in acute ischernic stroke? A Serbian experience with thrombolysis in ischemic stroke (SETIS) study[J]. Clin Neurol Neurosurg, 2009, 111(9): 729-732.
  • 5Arenillas JF, Sandoval P, P6rez de la Ossa N, et al. The metabolic syndrome is associated with a higher resistance to intravenous thrombolysis for acute isehemic stroke in women than in men [J]. Stroke, 2009, 40(2): 344-349.
  • 6Brait VH, Jackman KA, Walduck AK, et al. Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide[J]. J Cereb Blood Flow Metab, 2010, 30(7): 1306-1317.
  • 7Turaj W, Slowik A, Dziedzic T, et al. Increased plasma fibrinogen predicts one-year mortality in patients with acute ischemic stroke [J]. J Neurol Sci, 2006, 246(1-2): 13-19.
  • 8Sanak D, Herzig R, Zapletalova J, et al. Predictors of good clinical outcome in acute stroke patients treated with intravenous thrombolysis[J]. Acta Neurol Scand, 2011,123(5): 339-344.
  • 9Kimura K, Iguchi Y, Shibazaki K, et al. IV t-PA therapy in acute stroke patients with atrial fibrillation[J]. J Neurol Sci, 2009, 276 (1-2): 6-8.
  • 10Sanak D, Herzig R, Kral M, et al. Is atrial fibrillation associated with poor outcome after thrombolysis?[J]. J Neurol, 2010, 257(6): 999-1003.

共引文献55

同被引文献14

引证文献2

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部