摘要
目的探讨液基薄层细胞学(TCT)、活检病理在宫颈上皮内瘤变(CIN)及早期宫颈癌诊断分析。方法回顾性分析2018年9月—2019年9月在该院妇科治疗的413例宫颈上皮内瘤变及26例早期宫颈癌患者的临床资料,均经手术病理检查确诊。以此作为金标准,分析术前TCT及活检病理两种检查方法的诊断准确率。结果TCT检测结果显示,ASC-US 212例、ASC-H 46例、LSIL 93例、HSIL 19例、SCC 2例、反应性改变67例。活检病理结果显示,CIN 1级281例、CIN 2级40例、CIN 3级92例、SCC 26例。TCT在CIN与SCC的诊断学评价中的灵敏度为83.78%(346/413)、特异度为7.69%(2/26)、准确度为79.27%(348/439)。活检病理的灵敏度为100%(413/413)、特异度为96.15%(25/26)、准确度为99.77%(438/439)。活检病理的灵敏度、特异度和准确度明显高于TCT(χ2=12.374,25.978,11.893,P<0.05)。结论活检病理在宫颈上皮内瘤变及早期宫颈癌诊断效果优于TCT,与术后病理检查结果的符合率更高,但两者各具优缺点,临床工作中可互补使用,以提升整体诊断效果。
Objective To investigate the diagnosis and analysis of liquid-based thin-layer cytology(TCT)and biopsy pathology in cervical intraepithelial neoplasia(CIN)and early cervical cancer.Methods The clinical data of 413 patients with cervical intraepithelial neoplasia and 26 patients with early cervical cancer treated in gynecology in our hospital from September 2018 to September 2019 were retrospectively analyzed.All were confirmed by surgical pathology.Using this as the gold standard,the diagnostic accuracy of TCT and biopsy pathology were analyzed.Results The results of TCT showed that there were 212 cases of ASC-US,46 cases of ASC-H,93 cases of LSIL,19 cases of HSIL,2 cases of SCC,and 67 cases of reactivity.Biopsy pathological results showed that 281 cases were CIN grade 1,40 cases were CIN grade 2,92 cases were CIN grade 3,and 26 cases were SCC.TCT had a sensitivity of 83.78%(346/413),a specificity of 7.69%(2/26),and an accuracy of 79.27%(348/439)in the diagnostic evaluation of CIN and SCC.The sensitivity of the biopsy pathology was 100%(413/413),the specificity was 96.15%(25/26),and the accuracy was 99.77%(438/439).The sensitivity,specificity and accuracy of biopsy pathology were significantly higher than TCT(χ2=12.374,25.978,11.893,P<0.05).Conclusion Biopsy pathology is better than TCT in the diagnosis of cervical intraepithelial neoplasia and early cervical cancer,and has a higher coincidence rate with the results of postoperative pathological examinations,but both have advantages and disadvantages.They can be used in clinical work to improve the overall diagnosis effect.
作者
武蕾洁
黄信章
徐振勇
郑晓晖
WU Lei-jie;HUANG Xin-zhang;XU Zhen-yong;ZHENG Xiao-hui(Department of Pathology,Xiamen Changgeng Hospital,Xiamen,Fujian Province,361028 China)
出处
《中外医疗》
2020年第11期25-27,共3页
China & Foreign Medical Treatment
关键词
宫颈上皮内瘤变
早期宫颈癌
TCT
活检病理
诊断效果
Cervical intraepithelial neoplasia
Early cervical cancer
TCT
Biopsy pathology
Diagnostic effect
