摘要
目的探讨复方甘草酸苷片与他克莫司软膏联合红光治疗面部激素依赖性皮炎的疗效.方法2017年2月至2018年12月,解放军西部战区总医院皮肤科将80例[男7例,女73例,年龄19~58(30.25±6.83)岁]患者简单随机法分为试验组40例,对照组40例.两组患者均接受复方甘草酸苷片与他克莫司软膏治疗,在此基础上,试验组患者增加红光治疗.治疗4周后比较两组临床疗效.结果治疗4周后,试验组、对照组有效率分别为87.5%、62.5%,差异有统计学意义(χ^2=4.36,P<0.05).试验组与对照组比较,症状体征总积分下降明显,差异有统计学意义(t=3.10,P<0.05).药物不良反应发生在外用药局部,试验组4例,治疗组3例,表现为面部红斑加重或刺痛,均能忍受,继续使用1周不适反应逐渐消失.结论复方甘草酸苷片与他克莫司软膏联合红光治疗面部激素依赖性皮炎,疗效确切,安全性较好.
Objective To observe the clinical curative effect of compound glycyrrhizin tablets and tacrolimus ointmenta combined with photon therapy on hormone dependence facial dermatitis and the safety.Methods 80 cases were randomly divided into two groups:treatment group and control group,40 each;compound glycyrrhizin tablets and tacrolimus ointmenta were administrated to all the cases in both groups while photon therapy was added to cases in treatment group;a comparative study was made to observe the clinical effect 4 weeks after treatment between the two groups.Results Four weeks after treatment,the effective rate was 86.67%in treatment group and 63.33%in control group,the difference was of statistical significance(χ^2=4.36,P<0.05);the total scores of symp-toms and signs decreased obviously in both groups while the difference between the groups was of sta-tistical significance(t=3.10,P<0.05);topical medication led to drug adverse reaction in 4 cases in treatment group and 3 cases in control group with the manifestation of tolerable aggravated facial ery-thema and twinge while the adverse reaction disappeared gradually with the drug application keeping on for about 1 week.Conclusions Compound glycyrrhizin tablets and tacrolimus ointmenta com bined with photon therapy is of definite curative effect on hormone dependence facial dermatitis with good safety.
作者
张忠奎
何思娴
杨雨蒙
张桂祯
Zhang Zhongkui;He Sixian;Yang Yumeng;Zhang Guizhen(Departments of Dermatology,the General Hospital of Western Military Com-mand,Chengdu 610083,China;Departments of Information,the General Hospital of Western Military Com-mand,Chengdu 610083,China)
出处
《中华医学美学美容杂志》
2020年第2期135-137,共3页
Chinese Journal of Medical Aesthetics and Cosmetology
关键词
面部皮肤病
他克莫司
复方甘草酸苷
激素依赖性皮炎
红光治疗
Facial dermatoses
Tacrolimus
Compound glycyrrhizin
Hormone depend-ence dermatitis
Photon therapy
