摘要
目的观察中医推拿疗法治疗腹泻患儿的临床疗效和对腹泻患儿免疫功能和炎性因子的影响的影响。方法采用随机数字表法将80例小儿腹泻患儿分为两组,观察组和对照组各40例。对照组采用常规西医疗法,观察组采用常规西医疗法和中医推拿疗法。应用免疫比浊法检测两组患儿IgA、IgG和IgM体液免疫指标,采用流式细胞术检测T淋巴细胞亚群CD4+、CD8+比例及CD4+/CD8+比值;酶联免疫吸附法测定血清IL-10、IL-6和TNF-α指标水平;疗效判定标准依据《儿童腹泻病诊断治疗原则的专家共识》相关内容制定,总有效率为治愈率、显效率与有效率之和。结果治疗后,两组患儿体液免疫指标(IgA、IgG、IgM)较治疗前明显升高(P <0. 05),且观察组明显高于对照组(P <0. 05)。治疗后,两组患儿CD4+、CD4+/CD8+比例水平较治疗前明显升高(P <0. 05),CD8+水平较治疗前明显降低(P <0. 05),且观察组升高或降低程度均大于对照组(P <0. 05)。治疗前,两组患儿炎性因子水平(IL-10、IL-6和TNF-α)比较差异不明显(P <0. 05);治疗后,两组患儿炎性因子水平较治疗均明显降低(P <0. 05),观察组降低程度大于对照组(P <0. 05)。结论采用中医推拿疗法治疗小儿腹泻具有较好的临床疗效,能够调节患儿机体免疫功能,抑制炎性反应,缓解临床症状,值得推广应用。
Objective To observe the clinical efficacy of TCM Tuina therapy in children with diarrhea and the effects of immune function and inflammatory factors on children with diarrhea. Methods Eighty children with diarrhea were divided into the observation group and the control group by random number table method,40 cases in each. The control group was treated with conventional Western medicine,and the observation group was treated with conventional Western medicine and Chinese medicine. IgA,IgG and IgM were detected by immunoturbidimetry. The ratios of CD4+,CD8+ and CD4+/CD8+ in T lymphocyte subsets were detected by flow cytometry. The serum levels of IL-10,IL-6 and TNF-α were determined by enzyme-linked immunosorbent assay. The efficacy criteria was based on Expert Consensus on Children’s Diarrhea Diagnosis and Treatment Principle. The total effective rate was the sum of cure rate,significant efficiency rate and efficiency rate. Results After treatment,the humoral immunity indexes (IgA,IgG,IgM) of the two groups were significantly higher than those before treatment (P < 0. 05),and the observation group’s were significantly higher than those of the control group (P < 0. 05). After treatment,the levels of CD4+and CD4+/CD8+ in the two groups were significantly higher than those before treatment (P < 0. 05),and the levels of CD8+ were significantly lower than those before treatment (P < 0. 05),and the increase or decrease in the observation group was greater than that in the control group (P < 0. 05). Before treatment,the levels of inflammatory factors (IL-10,IL-6 and TNF-α) were not significantly different between the two groups (P > 0. 05). After treatment,the levels of inflammatory factors were significantly lower in both groups (P < 0. 05). The reduction degree of the observation group was greater than that in the control group (P < 0. 05). The total effective rate of the observation group was 97. 50% and that of the control group was 77. 50%. Conclusion The use of traditional Chinese medicine Tuina therapy for children with diarrhea has a good clinical effect,and can regulate the body’s immune function and inhibit the inflammatory response.
作者
周鸿雁
徐秀敏
ZHOU Hongyan;XU Xiumin(Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian 463000,Henan,China;The Second Hospital of Zhumadian,Zhumadian 463000,Henan,China)
出处
《实用中医内科杂志》
2020年第4期69-72,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
河南省中医药科学研究专项(2017ZY2083)。
关键词
腹泻
推拿疗法
免疫功能
炎性因子
diarrhea
Tuina therapy
immune function
inflammatory factor
