摘要
以苯乙胺为起始原料,经苯甲酰化、脱水环合、还原,然后经酒石酸拆分得到(S)-1-苯基-1,2,3,4-四氢异喹啉,优化条件下,产品总收率76.3%,产品纯度99.5%,其结构经熔点、~1H NMR、MS确证。工艺操作简单,无特殊设备要求,适合工业化生产。
(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline was prepared through a series of reactions including benzoylation,dehydration cyclization,reduction and resolution with D-tartaric acid using phenylethylamine as a starting material.The purity of the target product was of 99.5%,the overall yield was of 76.3%.The structure of(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline was confirmed by melting point,MS and^1H NMR.This process has many advantages including simple in operation,without special equipment requirements,and suitable for industrial production.
作者
孔祥雨
杨利
张彬
李新志
崔新强
刘文涛
张宁
王洪臣
KONG Xiang-yu;YANG li;ZHANG Bin;LI Xin-zhi;CUI Xin-qiang;LIU Wen-tao;ZHANG Ning;WANG Hong-chen(Shandong Academy of Pharmaceutical Science,Key Lab for Chemical Drug Research of Shandong Province,Jinan 250101,China;Shandong Haiyou Freda Pharmaceutical Co.,Ltd”Linyi 276700,China)
出处
《精细化工中间体》
CAS
2020年第1期44-47,共4页
Fine Chemical Intermediates
