摘要
目的:分析BRAFV600E基因突变与甲状腺乳头状癌(PTC)中央区淋巴结(CLN)转移的关系,探讨CLN转移的危险因素。方法:检测104例PTC病例BRAFV600E基因突变情况,分析该突变与PTC临床病理特征、超声特征的关系,单因素及多因素分析CLN转移的危险因素。结果:BRAFV600E基因突变与肿瘤最大径、肿瘤钙化、被膜外侵犯及CLN转移相关(P <0. 01),BRAFV600E基因突变和被膜外侵犯是CLN转移的独立因素(P <0. 01)。结论:BRAFV600E基因突变可为PTC手术CLN清扫提供基因依据。
Objective:To analyze the relationship between BRAFV600E mutation and central lymph node(CLN)metastasis of thyroid papillary carcinoma(PTC),and predict the risk factors of CLN metastasis.Methods:The BRAFV600E mutation was detected in 104 PTC cases,and the relationships between the mutation and clinicopathological,ultrasonic characteristics of PTC were analyzed.The risk factors of CLN metastasis were analyzed using single factor and multiple factors methods.Results:BRAFV600E mutation was associated with the maximum diameter of tumor,tumor calcification,extramembrane invasion and CLN metastasis(P<0.01).The BRAFV600E mutation and extramembrane invasion were the independent factors of CLN metastasis(P<0.01).Conclusions:BRAFV600E mutation can provide the genetic basis for CLN dissection in PTC surgery.
作者
于婧
王凤琴
姚文娟
吴冬梅
张伟强
王勤增
庞嗣裔
YU Jing;WANG Feng-qin;YAO Wen-juan;WU Dong-mei;ZHANG Wei-qiang;WANG Qin-zeng;PANG Si-yi(Department of Pathology,Hebei Petrochina Central Hospital,Langfang Hebei 065000;Department of Pathology,Langfang Municipal TCM Hospital,Langfang Hebei 065000,China)
出处
《蚌埠医学院学报》
CAS
2020年第4期493-496,共4页
Journal of Bengbu Medical College
