摘要
目的探讨胃肠道恶性肿瘤患者血清胆碱酯酶水平与预后的相关性。方法对2013年3月至2014年7月接受手术治疗的100例胃肠道肿瘤患者进行回顾性分析。患者均经病理学证实,除外乙肝等基础肝病的患者。统计患者的血清胆碱酯酶(CHE)、白蛋白(ALB)等,根据中位数分为高CHE组(>4620.5 U/L)、低CHE组(≤4620.5 U/L);高ALB组(>36.61 g/L)、低ALB组(≤36.61 g/L)。单因素和多因素分析影响胃肠道恶性肿瘤患者的预后因素。结果高CHE组共50例,其中高ALB 39例,低ALB 11例;低CHE组50例,其中高ALB 11例,低ALB 39例。血清ALB在不同胆碱酯酶水平患者中差异有统计学意义(P<0.01),胆碱酯酶越高,白蛋白越高。单因素分析:统计患者平均OS,年龄≤60岁组:46.90个月,年龄>60岁组:32.98个月(P=0.028);高白蛋白组:44.78个月,低白蛋白组:27.45个月(P=0.005);高胆碱酯酶组:46.43个月,低胆碱酯酶组:24.04个月(P=0.001);T1/2期组:51.50个月,T3/4期组:32.42个月(P=0.015);有淋巴结转移组:25.61个月,无淋巴结转移组:45.27个月(P<0.001);有脉管内癌栓组:24.03个月,无脉管内癌栓组:44.61个月(P<0.001)。年龄>60岁、低白蛋白、低胆碱酯酶、T分期为3/4、有淋巴结转移、有脉管内癌栓是影响患者OS的危险因素(P<0.05)。多因素分析:年龄>60岁、低胆碱酯酶、有淋巴结转移、有脉管内癌栓是影响患者OS的独立危险因素(P<0.05)。结论血清胆碱酯酶是营养指标,是胃肠道恶性肿瘤患者预后的影响因素,对于判断预后具有重要意义。
Objective To investigate the correlation between the serum cholinesterase(CHE)levels and the prognosis of patients with gastrointestinal malignant neoplasms.Methods A retrospective analysis was performed for 100 patients with gastrointestinal tumors who received surgical treatment in our hospital from March 2013 to July 2014,and all the patients were confirmed by pathological examination,excluding the patients with basic liver diseases such as hepatitis B.The serum levels of cholinesterase(CHE)and albumin(ALB)of patients were detected,then according the the detection results,these patients were divided into high CHE group(>4,620.5U/L),low CHE group(≤4,620.5U/L),high ALB group and low ALB group.The univariate analysis and multivariate analysis were used to evaluating of the factors affecting the prognosis of patients with gastrointestinal malignant neoplasms.Results There were 50 cases in high CHE group,of whom,there were 39 cases of high ALB,and 11 cases of low ALB,moreover,there were 50 patients in low CHE group,of whom,there were 11 cases of high ALB and 39 cases of low ALB.The differences of serum albumin in patients with different cholinesterase levels were statistically significant(P<0.01),and the higher the cholinesterase levels,the higher the albumin levels.The univariate analysis showed that the average OS in≤60 years age group was 46.90 months,which in>60 years age group was 32.98 months(P<0.05),and the the average OS in high albumin group was 44.78 months,which in low albumin group was 27.45 months(P<0.01),and high cholinesterase group was 46.43 months,and low cholinesterase group was 24.04 months(P<0.01),and which in T1/2 group was 51.50 months,the T3/4 group was 32.42 months(P<0.05).And lymph node metastasis group was 25.61 months,the no lymph node metastasis group was 45.27 months(P<0.01),and which in intravascular cancer thrombotic group was 24.03 months,the no intravascular cancer thrombotic group was 44.61 months(P<0.01).The multivariate analysis showed that patient’s age>60 years,low albumin(≤36.61g/L),low cholinesterase(≤4,620.5U/L),lymph node metastasis and intravascular cancer embolus were the risk factors affecting OS of patients(P<0.05).Conclusion The serum cholinesterase is a potential nutritional index,and the serum level of cholinesterase is a influencing factor affecting the prognosis of patients with gastrointestinal tumors,which is of great significance for the prognosis evaluation.
作者
王静宇
步玉晴
李影
何严璐琦
张洪珍
WANG Jingyu;BU Yuqing;LI Ying(Department of Oncology, Hebei Provincial People’s Hospital,Hebei, Shijiazhuang 050000,China)
出处
《河北医药》
CAS
2020年第9期1296-1300,共5页
Hebei Medical Journal
关键词
血清胆碱酯酶
胃肠道恶性肿瘤
预后
serum cholinesterase
gastrointestinal malignant tumor
prognosis
