摘要
目的探讨帕拉米韦氯化钠注射液在儿童流感合并肺炎治疗中的临床效果及不良反应。方法收集2018年11月~2019年3月河北省儿童医院住院患儿100例,按照随机数字表法将其分为对照组和观察组,每组各50例。对照组采用磷酸奥司他韦颗粒治疗,观察组采用帕拉米韦氯化钠注射液治疗。比较两组患者临床疗效、总有效率、病毒抗原转阴率、不良反应及5 d后血常规的变化情况。结果观察组发热、咳嗽、肺啰音持续时间和住院时间明显短于对照组,差异均有统计学意义(均P <0.05),而两组患者咽充血持续时间比较,差异无统计学意义(P> 0.05)。观察组总有效率、病毒抗原转阴率高于对照组,差异均有统计学意义(均P <0.05)。两组患者不良反应发生率比较,差异无统计学意义(P> 0.05)。两组患儿治疗前血常规各项指标比较,差异无统计学意义(P>0.05)。两组患儿治疗5 d后中性粒细胞百分比明显高于治疗前,且观察组高于对照组,C-反应蛋白明显低于治疗前,且观察组低于对照组,差异均有统计学意义(均P <0.05)。对照组治疗5 d后血小板高于治疗前,差异有统计学意义(P <0.05),但两组患儿治疗5 d后白细胞、红细胞、淋巴细胞百分比、血小板比较,差异无统计学意义(P>0.05)。结论在儿童流感合并肺炎的治疗过程中,帕拉米韦临床效果优于奥司他韦,可提高总有效率,缩短住院时间,并且病毒抗原转阴率较高,血常规恢复正常值较明显,起效快,值得临床推广。
Objective To investigate the clinical effects and adverse reactions of Peramivir Sodium Chloride Injection in the treatment of children with influenza and pneumonia. Methods A total of 100 children hospitalized in Hebei Children′s Hospital from November 2018 to March 2019 were collected and divided into the control group and the observation group according to the random number table method, with 50 cases in each group. The control group was treated with Oseltamivir Phosphate Granules, and the observation group was treated with Peramivir Sodium Chloride Injection. The clinical efficacy, total effective rate, viral antigen negative conversion rate, adverse reactions and blood routine changes after 5 days of the two groups during the treatment were compared. Results The duration of fever,cough, lung rales and hospital stay in the observation group were significantly shorter than those in the control group,with statistically significant differences(all P < 0.05). However, there was no statistically significant difference in the duration of pharyngeal congestion between the two groups(P > 0.05). The total effective rate and viral antigen negative conversion rate of the observation group were higher than those of the control group, with statistically significant differences(all P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P > 0.05). There was no statistically significant difference between the two groups in blood routine indexes before treatment(P > 0.05). After 5 days of treatment, the percentage of neutrophils in the two groups was significantly higher than before treatment, and the observation group was higher than the control group, while the C-reactive protein was significantly lower than before treatment, and the observation group was lower than the control group, with statistically significant differences(all P < 0.05). Platelets were higher in the control group 5 days after treatment than before treatment, and the difference was statistically significant(P < 0.05). However, there was no statistically significant difference in white blood cells, red blood cells, the percentage of lymphocytes and platelets between the two groups after 5 days of treatment(P > 0.05).Conclusion In the treatment of children with influenza and pneumonia, the clinical effect of Peramivir is better than Oseltamivir, can improve the total effective rate, shorten the hospital stay, and the virus antigen conversion rate is higher, blood routine to normal value is more obvious, the effect is fast, worthy of clinical promotion.
作者
安志华
张古英
东蕾
贾晨虹
付海燕
AN Zhihua;ZHANG Guying;DONG Lei;JIA Chenhong;FU Haiyan(Department of Pharmacy,Hebei Children′s Hospital,Hebei Province,Shijiazhuang 050031,China;Department of Gastroenterology,Hebei Children′s Hospital,Hebei Province,Shijiazhuang 050031,China)
出处
《中国医药导报》
CAS
2020年第10期153-156,共4页
China Medical Herald
基金
河北省医学科学研究课题(20190812)。
关键词
儿童
帕拉米韦
流感合并肺炎
临床效果
Children
Peramivir
Influenza and pneumonia
Clinical effect
