摘要
缺血性心脏病是全世界发病率与死亡率最高的疾病,严重威胁人们的生命与健康。西洋参在治疗心血管疾病中已经有了较为广泛的应用,具有抗心肌细胞凋亡、心律失常、改善梗死后心室重构、增强抗氧化酶活性等多种作用。关于西洋参主要有效成分对缺血性心脏病的保护作用研究较多,但作用机制尚不明确。本文通过综述近年来西洋参主要活性成分治疗缺血性心脏病的作用机制,从抑制心肌细胞凋亡、改善血液循环、抑制氧化应激等多种角度进行论述,为西洋参治疗缺血性心脏病提供依据,同时为进一步多靶点、多层次地开发应用西洋参及组方提供参考价值。
Ischemic heart disease is the disease with the highest morbidity and death rate in the world, which seriously threatens people′s life and health. Panax quinquefolium L. has been widely used in the treatment of cardiovascular diseases. It has many effects such as anti-apoptosis of myocardial cells, arrhythmia, improvement of ventricular remodeling after infarction, and enhancement of antioxidant enzyme activity. There are many studies on the protective effect of main active components of Panax quinquefolium L. on ischemic heart disease, but the mechanism is still unclear. This article reviews the mechanism of the main active ingredients of Panax quinquefolium L. in the treatment of ischemic heart disease in recent years, and expounds from a variety of perspectives, such as inhibiting myocardial cell apoptosis,improving blood circulation, and inhibiting oxidative stress. Based on this, it also provides reference value for further multi-target, multi-level development and application of Panax quinquefolium L. and the organization.
作者
刘岩松
王迪
郝珍珠
郭慧文
朴星虎
方美善
王冰梅
LIU Yansong;WANG Di;HAO Zhenzhu;GUO Huiwen;PIAO Xinghu;FANG Meishan;WANG Bingmei(School of Basic Medicine,Changchun University of Traditional Chinese Medicine,Jilin Province,Changchun 130117,China;Department of Traditional Chinese Medicine,China-Japan Friendship Hospital,Jilin University,Jilin Province,Changchun 130051,China)
出处
《中国医药导报》
CAS
2020年第10期42-45,共4页
China Medical Herald
基金
吉林省科技发展计划项目(20180201086YY)。
关键词
西洋参
缺血性心脏病
西洋参皂苷
Panax quinquefolium L.
Ischemic heart disease
American ginseng saponins
