摘要
PI3K/AKT/mTOR信号通路在中枢神经系统广泛分布,参与中枢神经系统细胞存活、自噬、神经发生、神经元增殖分化、突触可塑性等生理过程。中枢神经系统的许多疾病发生与其异常密切相关。阿尔茨海默病、帕金森病、亨廷顿病的PI3K/AKT/mTOR信号通路过度激活,导致自噬水平下降,无法清除病理蛋白沉积;抑郁症的PI3K/AKT/mTOR信号通路受抑制,导致突触可塑性受损;中枢神经系统肿瘤、皮质发育畸形则与PI3K/AKT/mTOR信号通路基因变异相关。该文对当前PI3K/AKT/mTOR信号转导通路与上述中枢神经系统疾病的研究进行综述,以期为以上疾病的进一步研究提供参考。
The PI3 K/AKT/mTOR signaling pathway is a widely scattered signaling pathway in central nervous system.It plays an important role in regulating cell survival,autophagy,neurogenesis,neuron proliferation,differentiation and synaptic plasticity in central nervous system.Its abnormity is identified in many central nervous system diseases.In Alzheimer’s disease,Parkinson’s disease and Huntington’s disease,the PI3 K/AKT/mTOR pathway is over-activated,resulting in decreased autophagy,pathological proteins accumulation,or neuron loss.In depression,the pathway is suppressed,which compromises synaptic plasticity.While its gene were mutated,the pathway facilitates central nervous system tumorigenesis and malformations of cortical development.In this paper,current studies regarding PI3 K/AKT/mTOR signal transduction pathway in central nervous system diseases are reviewed,in hope to provide reference for further studies on these diseases.
作者
张治楠
梁丽艳
连嘉惠
黄芸
钟正
曲姗姗
黄泳
ZHANG Zhinan;LIANG Liyan;LIAN Jiahui;HUANG Yun;ZHONG Zheng;QU Shanshan;HUANG Yong(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China)
出处
《实用医学杂志》
CAS
北大核心
2020年第5期689-694,共6页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81873359,81603474)
广东省自然科学基金项目(编号:2016A030313522,2016A030310383)
广东省科技计划项目(编号:2013A032500001)
广州市科技计划项目(编号:201707010041)
广东省第二批中医临床优秀人才研修项目[编号:粤中医办(2017?267)]
南方医院2018年度院长基金项目(编号:2018Z023)。
关键词
PI3K/AKT/mTOR信号通路
中枢神经系统
细胞存活
自噬
神经发生
神经元增殖分化
突触可塑性
阿尔茨海默病
帕金森病
亨廷顿病
抑郁症
中枢神经系统肿瘤
皮质发育畸形
PI3K/AKT/mTOR signaling pathway
central nervous system
cell survival
autophagy
neurogenesis
neuron proliferation and differentiation
synaptic plasticity
Alzheimer′s disease
Parkinson′s disease
Huntington′s disease
depression
central nervous system tumor
malformations of cortical development
