摘要
目的:探讨慢性肾脏病(CKD)患者血尿酸与动脉钙化的相关性。方法:将2016年4月至2019年1月在重庆三峡中心医院诊治的142例CKD患者作为研究对象,入院时采用X线监测动脉钙化情况,同时检测血尿酸(UA)、尿素氮(BUN)、血肌酐(SCr)、血钙(Ca)等血液生化指标。根据动脉钙化结果,将患者分为钙化组(66例)和非钙化组(76例),对钙化组患者进行血液透析滤过,检测血液透析滤过后动脉钙化评分和UA水平,分析动脉钙化评分与UA的关系及影响动脉钙化的危险因素。结果:钙化组高血压比例、慢性肾炎史比例、TG、CRP及24h尿蛋白定量显著高于非钙化组(P<0.05),Hb、eGFR低于非钙化组(P<0.05);规律透析6个月后钙化组钙化积分及UA水平均较透析前下降,差异有统计学意义(P<0.05);CKD患者动脉钙化评分与UA水平呈正相关(P<0.05);UA和eGFR是影响CKD患者动脉钙化的危险因素。结论:血尿酸可加重CKD患者动脉钙化,血液透析治疗能清除UA水平,透气前提前干预尿酸治疗以及联合充分透析治疗可能是改善动脉钙化的有效方法。
Objective:To investigate the correlation between serum uric acid with coronary artery calcification in patients with chronic kidney disease(CKD).Methods:142 patients with CKD hospitalized in Chongqing Three Gorges Central Hospital from April 2016 to January 2019 were selected as the research subjects.The arterial calcification was monitored by X-ray at admission.And Simultaneous determination of serum uric acid(UA),urea nitrogen(BUN),serum creatinine(SCr),serum calcium and other blood biochemical indicators.According to the results of coronary artery calcification,the patients were divided into calcification group(66 cases)and non-calcification group(76 cases),Arterial calcification scores and UA levels after hemodialysis were measured,the relationship between Arterial calcification scores with UA and the risk factors of coronary artery calcification were analyzed.Results:The TG,CRP,24h urinary protein,proportion of hypertension and chronic nephritis history in calcification group were significantly higher than those in non-calcification group(P<0.05),while Hb and eGFR were lower than those in non-calcification group(P<0.05);the UA level before dialysis in calcification group was higher than that in non-calcification group(P<0.05),and the calcification scores and UA level after dialysis were lower than those before dialysis(P<0.05);there was a positive correlation between Arterial calcification scores with UA level in CKD patients(P<0.05);UA and eGFR were risk factors for coronary artery calcification in CKD patients.Conclusion:Serum uric acid can aggravate arterial calcification in patients with CKD.Early intervention of uric acid therapy and adequate dialysis may be an effective way to improve arterial calcification.
作者
周龙
胡春兰
吴泽成
赵欢
ZHOU Long;HU Chunlan;WU Zecheng(Chongqing Three Gorges Central Hospital, Chongqing 404000, China)
出处
《河北医学》
CAS
2020年第4期589-594,共6页
Hebei Medicine
基金
重庆市自科面上项目,(编号:cstc2019jcyj-msxmx0801)。
关键词
慢性肾脏病
血尿酸
动脉钙化
Chronic kidney disease
Blood uric acid
Coronary artery calcification
