摘要
目的分析高龄急性胆管炎合并胆总管结石患者行内镜逆行胰胆管造影(endoscopic retrograde cholangio pancr eatography,ERCP)的治疗效果。方法选择2015年6月至2018年6月西南医科大学附属成都三六三医院收治的104例高龄急性胆管炎合并胆总管结石患者为研究对象,按随机数字表法将其分为对照组和观察组,每组各52例。对照组患者采取胆管切开取石术治疗,观察组患者采取ERCP治疗。比较两组患者治疗总有效率、白介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平及术后并发症发生情况。结果观察组患者治疗总有效率显著高于对照组(P<0.05),术后并发症发生率显著低于对照组(P<0.05)。治疗后,两组患者IL-6、TNF-α水平均显著低于本组治疗前(均P<0.05),且观察组患者血清IL-6、TNF-α水平均显著低于同期对照组(均P<0.05)。结论高龄急性胆管炎合并胆总管结石患者采用ERCP治疗,能够明显提高治疗效果,有效降低炎性因子水平,减少术后并发症。
Objective To study the effect of endoscopic retrograde cholangiopancreatography(ERCP)in elderly patients with acute cholangitis complicated with choledocholithiasis.Method From June 2015 to June 2018,104 elderly patients with acute cholangitis complicated with choledocholithiasis admitted to Chengdu 363 Hospital Affiliated to Southwest Medical University were selected as subjects,they were divided into control group(n=52)and observation group(n=52)according to the method of random number table.The patients in control group were treated with choledocholithotomy,and patients in observation group were treated with ERCP.The total effective rate,the levels of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and postoperative complications were compared between the two groups.Result The total effective rate of observation group was significantly higher than that of control group(P<0.05),and the incidence of postoperative complications was significantly lower than that of control group(P<0.05).After treatment,the levels of IL-6 and TNF-α in both groups were significantly lower than those before treatment(all P<0.05),and the levels of serum IL-6 and TNF-αin observation group were significantly lower than those in control group(all P<0.05).Conclusion The treatment of ERCP in elderly patients with acute cholangitis complicated with choledocholithiasis can significantly improve the therapeutic effect,effectively reduce the levels of inflammatory factors,and reduce postoperative complications.
作者
谭琴
母齐鸣
杨娟
李春林
Tan Qin;Mu Qiming;Yang Juan;Li Chunlin(Department of Hepatobiliary and Pancreatic Surgery,Chengdu 363 Hospital Affiliated to Southwest Medical University,Chengdu 610041,China)
出处
《中国医学前沿杂志（电子版）》
2020年第4期76-79,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
四川省卫生和计划生育委员会科研课题(18PJ396)。
关键词
内镜逆行胰胆管造影
高龄
急性胆管炎
胆总管结石
Endoscopic retrograde cholangiopancreatography
Elderly
Acute cholangitis
Choledocholithiasis
