摘要
目的:探究风咳汤联合穴位贴敷治疗感染后咳嗽的临床疗效,以期丰富治疗方法,为治疗感染后咳嗽提供科学依据。方法:选取2017年1月至2018年1月南京市中西医结合医院收治的感染后咳嗽患者88例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组44例。对照组予常规治疗,观察组在对照组基础上加用风咳汤联合穴位贴敷治疗,均治疗2周。观察比较2组患者采用不同方法治疗前、后中医证候积分、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、诱导痰上清液中P物质(SP)含量水平变化情况。治疗过程中收集不良反应资料,结束治疗后比较2组疗效。结果:1)2组患者完成治疗方案后,中医症候积分较治疗前均显著下降,观察组显著优于对照组,差异有统计学意义(P<0.05);2)治疗后2组患者IL-8、TNF-α、SP含量均较治疗前显著下降,且观察组优于对照组,差异有统计学意义(P<0.05);3)观察组患者临床控制率、总有效率明显高于对照组,差异有统计学意义(P<0.05)。4)2组患者ALT、AST、CCr、BUN水平和不良反应发生率比较,差异无统计学意义(P>0.05)。结论:风咳汤联合穴位贴敷治疗感染后咳嗽能提高疗效,降低炎性反应水平,改善症状和生命质量。
Objective:To explore the curative effects of Fengke Decoction combined with Acupoint Application on post-infection cough,so as to enrich the treatment methods and provide a strong basis for the treatment of post-infection cough.Methods:A total of 88 patients with postinfectious cough were enrolled in Nanjing Integrated Traditional Chinese and Western Hospital from January 2017 to January 2018.The patients were divided into a control group(44 cases)and an experimental group(n=44 cases)according to random number table.The control group was given routine treatment,and the experimental group was given Fengke Decoction combined with Acupoint Application on the basis of the control group for 2 weeks.TCM syndrome scores before and after treatment with different methods,and the interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),the level of substance P(SP)in induced sputum supernatant were observed and the adverse reactions were collected during treatment.The efficacy was observed after treatment.Results:1)After completing the treatment regimen in the 2 groups,the TCM symptom scores were significantly lower than those before the treatment,and the observation group was significantly better than that of the the control group(P<0.05);2)the levels of IL-8,TNF-α,and SP in the 2 groups of patients were significantly lower than those tbefore treatment,and the observation group was better than the control group(P<0.05);3)The clinical control rate and total effective rate of the patients in the observation group were significantly higher than those in the control group(P<0.05).4)There was no significant difference in the levels of ALT,AST,CCr,BUN and the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Fengke Decoction combined with acupoint Application can improve the curative effects,reduce the level of inflammation,improve the symptoms and quality of life.
作者
马士荣
王东旭
MA Shirong;WANG Dongxu(Nanjing Integrated Traditional Chinese and Western Hospital,Nanjing 210014,China)
出处
《世界中医药》
CAS
2020年第6期910-914,共5页
World Chinese Medicine
基金
江苏省卫生计生委2016年度面上科研课题(H201607)。
关键词
风咳汤
穴位贴敷
感染后咳嗽
炎性反应因子
中医证候积分
临床疗效
药物不良反应
临床分析
Fengke Decoction
Acupoint Application
Cough after infection
Inflammatory factors
TCM syndrome score
Clinical efficacy
Adverse drug reactions
Clinical analysis
