摘要
目的探讨中医药对复发缓解型多发性硬化(RRMS)患者的复发与残疾的影响。方法对2011年1月至2018年12月北京中医药大学东直门医院脑病科门诊RRMS患者进行电话回访,采用结构化的"多发性硬化门诊电话回访表"进行调查,包括一般资料、诊断、疾病信息、合并症、个人史、用药信息、残疾程度等。分别以复发率、残疾程度为因变量,采用Logistic回归分析方法探讨中药月使用率对患者复发、残疾的影响。结果共随访50例RRMS患者,回归分析结果表明,存在反复发作的症状与高复发率具有较强的关联(OR=13.51);同时首次发作运动障碍(OR=112.73)、遗留症状(OR=10.91)均是残疾的危险因素,而中药月使用率则是残疾的潜在保护因素(OR=0.03)。结论较高的中药月使用率是RRMS残疾的潜在保护因素,平均每月中药治疗1周以上,能降低残疾的风险。
Objective To explore effects of traditional Chinese medicine(TCM) on relapse and disability in patients with relapsing-remitting multiple sclerosis(RRMS). Methods Telephone follow-ups were conducted on patients with RRMS admitted in the outpatient of encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine from January 2011 to December 2018. The survey was conducted by using a structured "Multiple Sclerosis Outpatient Telephone Follow-up Form", which included general information, diagnosis, disease information, comorbidities, personal history, medication information, degree of disability, etc. Taking the recurrence rate and degree of disability as dependent variables, logistic regression analysis was used to explore the effects of monthly usage rate of Chinese materia medica on relapse and disability. Results A total of 50 RRMS patients were interviewed by telephone follow-ups. The results of logistic regression showed that there was a strong correlation between repeated symptoms and high relapse rate(OR=13.51). And it was found that motor disturbance at first onset(OR=112.73) and residual symptoms were risk factors of disability(OR=10.91). Meanwhile the monthly usage rate of Chinese materia medica was a protective factor of disability(OR=0.03). Conclusion High monthly usage rate of Chinese materia medica was a potential protective factor of disability in RRMS. Patients treated with Chinese materia medica for more than 1 week per month have lower risk of disability.
作者
谢瑶
严冬
孟甜甜
李婷婷
杨芩瑜
王思锦
解小龙
高颖
XIE Yao;YAN Dong;Meng Tiantian;LI Tingting;YANG Qinyu;WANG Sijin;XIE Xiaolong;GAO Ying(Dongzhimen Hospital,Beijing University of Chinese Medcine,Beijing,100700)
出处
《中医杂志》
CSCD
北大核心
2020年第6期509-513,共5页
Journal of Traditional Chinese Medicine
关键词
多发性硬化
复发缓解型
复发
残疾
中药使用率
multiple sclerosis
relapsing-remitting
relapse
disability
usage rate of Chinese materia medica
