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直肠癌新辅助治疗后复发及远处转移的研究进展 被引量:7

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摘要 结直肠癌是中国常见的恶性肿瘤,位居恶性肿瘤死因的第3位。在2012年诊断的全球1361000例结直肠癌中,中国结直肠癌患者占18.6%。手术是直肠癌的主要治疗手段。多项大型Ⅲ期临床研究结果显示,新辅助放化疗(nCRT)较术后放化疗能有效降低患者的术后5年局部复发率,提高括约肌保存率。nCRT已被美国癌症联合委员会确定为Ⅱ、Ⅲ期直肠癌的标准治疗方法。虽然nCRT能降低患者的局部复发率,但在减少远处转移的发生和延长生存期方面并无获益。本文探讨nCRT后局部进展期直肠癌患者肿瘤复发及远处转移的模式,并探讨患者无生存获益的原因。
出处 《癌症进展》 2020年第5期444-447,共4页 Oncology Progress
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  • 1Michelassi F, Block GE, Vannucci L, Montag A, Chappell R. A5- to 21-year follow-up and analysis of 250 patients with rectaladenocarcinoma. Ann Surg 1988; 208: 379-389 [PMID: 3421761DOI: 10.1097/00000658-198809000-00016].
  • 2Harrison JC, Dean PJ, el-Zeky F, Vander Zwaag R. From Dukesthrough Jass: pathological prognostic indicators in rectal cancer.Hum Pathol 1994; 25: 498-505 [PMID: 8200644 DOI: 10.1016/0046-8177(94)90122-8].
  • 3Blenkinsopp WK, Stewart-Brown S, Blesovsky L, Kearney G,Fielding LP. Histopathology reporting in large bowel cancer. JClin Pathol 1981; 34: 509-513 [PMID: 7251893 DOI: 10.1136/jcp.34.5.509].
  • 4Freedman LS, Macaskill P, Smith AN. Multivariate analysisof prognostic factors for operable rectal cancer. Lancet 1984; 2:733-736 [PMID: 6148482 DOI: 10.1016/S0140-6736(84)92636-9].
  • 5Knudsen JB, Nilsson T, Sprechler M, Johansen A, Christensen N.Venous and nerve invasion as prognostic factors in postoperativesurvival of patients with resectable cancer of the rectum. DisColon Rectum 1983; 26: 613-617 [PMID: 6872793 DOI: 10.1007/BF02552975].
  • 6Talbot IC, Ritchie S, Leighton MH, Hughes AO, Bussey HJ,Morson BC. The clinical significance of invasion of veins byrectal cancer. Br J Surg 1980; 67: 439-442 [PMID: 7388345 DOI:10.1002/bjs.1800670619].
  • 7Horn A, Dahl O, Morild I. Venous and neural invasion as predictorsof recurrence in rectal adenocarcinoma. Dis Colon Rectum 1991;34: 798-804 [PMID: 1914747 DOI: 10.1007/BF02051074].
  • 8Smith NJ, Barbachano Y, Norman AR, Swift RI, Abulafi AM,Brown G. Prognostic significance of magnetic resonance imagingdetectedextramural vascular invasion in rectal cancer. Br J Surg2008; 95: 229-236 [PMID: 17932879 DOI: 10.1002/bjs.5917].
  • 9Littleford SE, Baird A, Rotimi O, Verbeke CS, Scott N.Interobserver variation in the reporting of local peritonealinvolvement and extramural venous invasion in colonic cancer.Histopathology 2009; 55: 407-413 [PMID: 19817891 DOI: 10.1111/j.1365-2559.2009.03397.x].
  • 10Messenger DE, Driman DK, McLeod RS, Riddell RH, Kirsch R.Current practice patterns among pathologists in the assessmentof venous invasion in colorectal cancer. J Clin Pathol 2011; 64:983-989 [PMID: 21697290 DOI: 10.1136/jclinpath-2011-200156].

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