摘要
目的探究银杏叶联合尼可地尔对药物洗脱支架治疗后老年冠心病患者多支病变的疗效。方法选取我院经药物洗脱支架治疗后的老年冠心病多支病变患者128例,根据治疗方案的不同将其分为研究组和对照组各64例。2组入院后均给予尼可地尔治疗,在此基础上,研究组加银杏叶连续治疗4周。比较2组治疗前后心绞痛、左心室功能及斑块稳定性等,观察2组治疗后6个月复发性心绞痛发生情况。结果研究组总有效率明显高于对照组(95.31%vs 81.25%,P=0.013);治疗后4周,研究组心绞痛发作次数、心绞痛持续时间、硝酸甘油用量均明显低于对照组(P<0.01);治疗后研究组左心室收缩末期内径、高敏C反应蛋白、白细胞介素6等均明显低于对照组(P<0.01),LVEF、心排血量明显高于对照组(P<0.01);治疗后6个月研究组心绞痛复发率显著低于对照组(7.81%vs 23.44%,P<0.05)。结论银杏叶联合尼可地尔可减少经药物洗脱支架治疗后老年冠心病多支病变患者复发性心绞痛的发生,同时能缓解血管炎性反应,利于提升斑块稳定性。
Objective To study the effect of Ginkgo biloba leaves combined with nicorandil on multivessel lesions in elderly CHD patients after drug-eluting stenting.Methods One hundred and twenty-eight elderly CHD patients with multivessel lesions who underwent drug-eluting stenting were divided into study group(n=64)and control group(n=64)according to their treatment plan.The patients in control group were treated with nicorandil only while those in study group were treated with nicorandil plus Ginkgo biloba leaves for 4 weeks after admission.The incidence of angina pectoris,left ventricular function,plaque stability before and after drug-eluting stenting were compared between the 2 groups.Results The total effective rate of Ginkgo biloba leaves combined with nicorandil was significantly higher in study group than in control group(95.31%vs 81.25%,P=0.013).The number of angina pectoris attacks was significantly smaller,the duration of angina pectoris and left ventricular end systolic diameter were significantly shorter,and the amount of used nitroglycerin,serum levels of hs-CRP,IL-6 were significantly lower while the LVEF and cardiac output were significantly higher in study group than in control group after 4 weeks of drug-eluting stenting(P<0.01).The incidence of recurrent angina pectoris was significantly lower in study group than in control group after 6 months of drug-eluting stenting(7.81%vs 23.44%,P<0.05).Concluesion Ginkgo biloba leaves combined with nicorandil can reduce the incidence of recurrent angina pectoris,alleviate the vascular inflammatory reation and improve the plaque stability in elderly CHD patients with multivessel lesions after drug-eluting stenting.
作者
常培学
李海波
许振培
Chang Peixue;Li Haibo;Xu Zhenpei(Department of Geriatric Endocrinology,Haikou No.4 People's Hospital,Haikou 571100,Hainan Province,China)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2020年第3期265-268,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
海南省卫生厅科研基金项目(琼卫2012PT-97)。
关键词
银杏
尼可地尔
药物洗脱支架
冠心病
C反应蛋白质
ginkgo biloba
nicorandil
drug-eluting stents
coronary disease
C-reactive protein
