摘要
目的探讨血清瘦素、脂联素、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平与强直性脊柱炎(AS)患者骨密度(BMD)的相关性。方法将48例AS患者与41名性别和年龄匹配的对照组进行比较。测定血清瘦素、脂联素、TNF-α和IL-6水平。使用双能X射线吸收测定法评估腰椎(L1-L4)和股骨颈的BMD和身体组成。评估脂肪因子、白细胞介素-6和肿瘤坏死因子-α水平与强直性脊柱炎患者骨密度相关性。结果AS患者和对照组具有相似的脂肪量和瘦体重。AS患者的血清IL-6、TNF-α、瘦素和脂联素水平显著高于对照组。骨质疏松症(OP)患者的IL-6、TNF-α、瘦素和脂联素水平高于非OP的患者;在调整体质指数后,这种差异仍然存在。结论AS患者的IL-6、TNF-α、瘦素和脂联素水平升高与BMD降低有关。
Objective To identify correlations between the serum levels of leptin,adiponectin,interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)and bone mineral density(BMD)in patients with ankylosing spondylitis(AS).Methods Forty-eight patients with AS were compared with 41 sex-and age-matched controls.The serum leptin,adiponectin,TNF-α,and IL-6 concentrations were determined.Body composition and BMD of the lumbar vertebrae(L1-L4)and femoral neck were evaluated using dual-energy X-ray absorptiometry.This study assessed the between the serum levels of adipokines,interleukin-6,and tumor necrosis factor-alpha and BMD in patients with AS.Results Patients with AS and controls had similar fat mass and lean mass.Serum interleukin-6,tumor necrosis factor-alpha,leptin,and adiponectin concentrations were significantly higher in AS patients than those in the control group.The levels of interleukin-6,tumor necrosis factor-alpha,leptin,and adiponectin in patients with osteoporosis(OP)were higher than those without OP;and the difference remained after adjusting for body mass index.Conclusion Elevated interleukin-6,tumor necrosis factor-a,leptin,and adiponectin concentrations are associated with reduction of BMD in patients with AS.
作者
陈国阳
苏松森
张清平
陈永旺
CHEN Guoyang;SU Songsen;ZHANG Qingping;CHEN Yongwang(Department of Rheumatology,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,Fujian,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第3期398-402,共5页
Chinese Journal of Osteoporosis
