摘要
目的:观察益气养阴化瘀方治疗对肺癌术后患者复发和转移的影响。方法:将接受手术治疗的非小细胞肺癌患者88例随机分为2组,对照组44例术后行常规GP方案治疗,观察组44例在对照组的基础上加服益气养阴化瘀方治疗8周,观察患者治疗后复发转移情况,血清肿瘤标志物[血管内皮生长因子(VEGF)、癌胚抗原(CEA)、糖链抗原CA199、CA125、CA50]含量及免疫功能[T淋巴细胞(CD8^+、CD4^+、CD3^+、CD4^+/CD8^+)和自然杀伤细胞(NK)]改变情况。结果:随访12个月,观察组患者复复发2例(4.55%),转移10例(22.73%);对照组复发3例(6.82%),转移12例(27.27%);观察组复发率、转移率均低于对照组,但差异无统计学意义(P>0.05)。治疗后及随访12个月,观察组血清VEGF、CEA、CA199、CA50含量均较治疗前显著降低(P<0.05)。治疗后,对照组血清VEGF、CEA、CA199、CA50含量均较治疗前显著降低(P<0.05);随访12个月,对照组血清VEGF含量降低,CA125、CA50含量升高(P<0.05)。随访12个月,观察组患者血清VEGF、CEA、CA199、CA125及CA50含量均明显低于对照组(P<0.05)。随访12个月,观察组患者CD8^+、CD4^+、CD3^+含量均较治疗前及对照组同时间点显著升高(P<0.05)。治疗后,对照组患者CD3^+、CD4^+/CD8^+比值均较治疗前显著降低(P<0.05)。治疗后,观察组CD3^+、CD4^+/CD8^+比值均较对照组升高(P<0.05)。2组治疗前后NK值变化不显著(P>0.05)。结论:在肺癌术后GP方案治疗的基础上,加用益气养阴化瘀方可降低患者复发转移率、血清肿瘤标志物含量,提高患者机体免疫功能。
Objective: To observe the effect of Yiqi Yangyin Huayu prescription on postoperative recurrence and metastasis of lung caner. Methods:Divided 88 cases of patients with non-small cell lung cancer undergoing operation into two groups randomly,44 cases in each group. The control group received routine GP regimen,while the observation group additionally received the oral administration of Yiqi Yangyin Huayu prescription. The treatment of both groups lasted for 8 weeks. After treatment,observed the status of recurrence and metastasis,the contents of serum tumor markers [vascular endothelial growth factor(VEGF), carcinoembryonic antigen(CEA), carbohydrate antigen CA199, CA125, CA50] and changes of immune function [T lymphocytes(CD8^+, CD4^+, CD3^+, CD4^+/CD8^+) and natural killer cell] in both groups.Results:After follow-ups for 12 months,2 cases recurred(4.55%) and 10 cases transferred(22.73%) in the observation group;3 cases recurred(6.82%) and 12 cases transferred(27.27%) in the control group;the recurrence rate and the metastasis rate in the observation group were both lower than those in the control group, but there was no significant difference being found(P>0.05). After treatment and follow-ups for 12 months,the contents of serum VEGF,CEA,CA199 and CA50 in the observation group were significantly lower than those before treatment(P<0.05). After treatment, the contents of serum VEGF,CEA,CA199 and CA50 in the control group were significantly lower than those before treatment(P<0.05);after follow-ups for 12 months,the content of VEGF was decreased,and the contents of CA125 and CA50 were increased(P<0.05). After follow-ups for 12 months,the contents of serum VEGF,CEA,CA199,CA125 and CA50 were significantly lower than those in the control group(P<0.05). After follow-ups for 12 months,the contents of CD8^+,CD4^+ and CD3^+ were in the observation group were significantly higher than those before treatment and in the control group in the same time point(P<0.05). After treatment, the ratios of CD3^+, CD4^+/CD8^+ in the control group were significantly lower those before treatment(P<0.05). After treatment,the ratios of CD3+,CD4+/CD8+ in the observation group were higher those in the control group(P<0.05). There was no significant difference being found in the values of NK in both groups before and after treatment(P>0.05). Conclusion: The additional application of Yiqi Yangyin Huayu prescription based on GP regimen after operation for lung cancer can decrease the rate of recurrence and metastasis and the contents of serum tumor markers,and promote bodily immune function.
作者
李华
郭丽
憨镔
李蕾
黄雪青
LI Hua;GUO Li;HAN Bin;LI Lei;HUANG Xueqing
出处
《新中医》
CAS
2020年第4期118-121,共4页
New Chinese Medicine
关键词
肺癌
手术
复发
转移
GP方案
益气养阴化瘀方
Lung cancer
Operation
Recurrence
Metastasis
GP regimen
Yiqi Yangyin Huayu prescription
