摘要
目的探讨厄贝沙坦联合胺碘酮治疗心力衰竭合并心律失常的效果。方法选取2017年1月~2019年1月我院收治的60例心力衰竭合并心律失常患者进行回顾性研究,按照治疗方法将患者分为对照组(30例)、观察组(30例)。对照组患者采用胺碘酮治疗,观察组患者采用胺碘酮+厄贝沙坦治疗。比较两组患者的临床疗效、心功能指标、心率震荡指标、不良反应总发生率。结果观察组患者的临床总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,观察组患者的左心射血分数、每搏输出量均高于对照组,其N末端脑钠利钛(NT-proBNP)水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的震荡初始值(TO)、震荡斜率(TS)、心率变异性时域值(SDNN)均高于对照组,差异均有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论厄贝沙坦与胺碘酮联合应用可更加有效地改善心力衰竭合并心律失常患者的心功能和心率情况,疗效显著,安全性良好。
Objective To investigate the effect of Irbesartan combined with Amiodarone in the treament of heart failure combined with arrhythmia.Methods Sixty cases of patients with heart failure and arrhythmia treated in our hospital from January 2017 to January 2019 were selected for retrospective study.According to the treatment methods,the patients were divided into control group(30 cases)and observation group(30 cases).The control group was treated with Amiodarone,while the observation group was treated with Amiodarone combined with Irbesartan.The clinical efficacy,cardiac function indicators,heart rate turbulence indicators and total incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 93.33%,which was higher than 73.33%of the control group,the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction and stroke output of the observation group were higher than those of the control group,and the N-terminal brain natriuretic(NT-proBNP)level of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the initial value of oscillation(TO),oscillation slope(TS),time-domain value of heart rate variability(SDNN)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Irbesartan and Amiodarone can improve the heart function and heart rate of patients with heart failure and arrhythmia more effectively,the curative effect is remarkable,the safety is good.
作者
李丽曼
杨专青
LI Li-man;YANG Zhuan-qing(Department of Pharmacy,Tangxia Hospital of Dongguan City,Guangdong Province,Dongguan 523718,China)
出处
《中国当代医药》
2020年第6期156-159,共4页
China Modern Medicine
基金
广东省东莞市社会科技发展(一般)项目(201950715032918)。
