摘要
目的:观察芪藤汤辨证加减治疗老年骨质疏松症的疗效和安全性。方法:选取2014年6月至2016年6月苏州市中医医院骨伤科特需门诊诊治的老年骨质疏松症男性患者60例,按照随机数字表法分为治疗组和对照组各30例。治疗组给予芪藤汤辨证加减治疗,对照组给予碳酸钙D3片、阿仑膦酸钠片治疗,比较两组患者治疗前后下腰痛LBOS评分、腰椎骨密度、Ⅰ型前胶原氨基端前肽和血清Ⅰ型胶原交联羧基末端肽指标水平,并检测安全性指标。结果:治疗组治疗后LBOS评分为(60.4±11.9)分,对照组LBOS评分为(55.6±10.8)分,治疗组高于对照组,差异有统计学意义(P<0.05);两组治疗后腰椎骨密度、PINP、S-CTX水平均较治疗前改善,且治疗组治疗后腰椎骨密度高于对照组,差异有统计学意义(P<0.05);治疗过程中,两组患者血常规、肝肾功能均未见异常,且患者未出现药物过敏或不适症状。结论:芪藤汤能有效提高老年骨质疏松症患者骨密度,改善临床症状,可能与其有效调节骨转换代谢平衡相关,且安全性较高。
Objective:To observe the clinical curative effect of Qiteng Decoction(芪藤汤,QTD) on osteoporosis in the elderly and its safety.Methods:A total of 60 elderly male patients with osteoporosis treated in our hospital′s special outpatient of Orthopaedics and Traumatology from June 2014 to June 2016 were selected and divided into the treatment group and the control group,with 30 cases in each group according to the random number table method.The treatment group was treated with QTD and the control group was treated with calcium carbonate D3 and alendronate sodium tablets.Then LBOs score of low back pain,lumbar bone density,amino terminal pro peptide of type I procollagen and cross-linked carboxy terminal peptide of type I collagen in serum were compared before and after the treatment,and the safety indexes were also measured.Results:After the treatment,the LBOs score of the treatment group was(60.4±11.9) and that of the control group was(55.6±10.8).The above index of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the bone density,PINP and S-CTX levels of the two groups were improved,and the above indexes of the treatment group was higher than those of the control group and all the differences were statistically significant(P<0.05).During the treatment,the blood routine test,liver and kidney function of the two groups were normal,and the patients did not have drug allergy or discomfort symptoms.Conclusion:QTD can effectively improve the bone density and clinical symptoms of the elderly osteoporosis patients,which may be related to the effective regulation of bone turnover and metabolism balance,and has high safety.
作者
蔡学峰
沈晓峰
CAI Xue-feng;SHEN Xiao-feng(Suzhou Hospital of TCM,Suzhou,Jiangsu,China,215000)
出处
《河南中医》
2020年第1期117-119,共3页
Henan Traditional Chinese Medicine
关键词
芪藤汤
骨质疏松症
骨密度
Ⅰ型前胶原氨基端前肽
血清Ⅰ型胶原交联羧基末端肽
Qiteng Decoction(QTD)
osteoporosis
bone density
type Ⅰ procollagen amino terminal peptide
serum type Ⅰ collagen cross linked carboxy terminal peptide
