摘要
目的:观察益气清热活血方联合西药防控卒中后医院感染效果及对炎症因子作用机制。方法:选取急性脑卒中患者174例,随机分为对照组和观察组各87例。对照组采用基础治疗,观察组联合益气清热活血方。比较两组医院感染率、感染部位、抗菌药物使用率、使用时间和治疗前后神经功能缺损积分(NIHSS)、日常生活能力评分(ADL)及感染确诊时(T0)、抗感染治疗3 d时(T1)、抗感染治疗7 d时(T2)患者炎症因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果:对照组医院感染率与观察组比较,差异无统计学意义(P>0.05);观察组抗菌药物使用率及使用时间分别低于对照组,差异有统计学意义(P<0.05)。治疗后观察组NIHSS评分低于对照组、ADL评分高于对照组,差异有统计学意义(P<0.05)。T0、T1时,观察组IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。结论:益气清热活血方通过调节机体免疫能力、减少炎症因子过度表达而能维持抗炎和致炎平衡,有助于降低脑卒中患者医院感染率,促进患者早日康复充。
Objective To observe the effect of Yiqi Qingre Huoxue Prescription combined with western medicine on preventing and controlling nosocomial infection after stroke and the mechanism of its action on inflammatory factors.Methods 174 patients with acute stroke were randomly divided into control group and observation group,87 cases each..The control group was only treated with basic treatment,while the observation group was combined with Yiqi Qingre Huoxue recipe.The hospital infection rate,infection site,antibiotic use rate,time of use,and neurological deficit scores(NIHSS),daily living ability score(ADL),and infection diagnosis(T0),and anti-infective treatment for 3 days were compared between the two groups(T1),inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels in patients with anti-infective treatment at 7 days(T2).Results There was no significant difference in nosocomial infection rate between the control group and the observation group(P>0.05).The use rate and time of antibiotics in the observation group were lower than those in the control group(P<0.05).After treatment,the NIHSS score of the observation group was lower than that of the control group,and the ADL score was higher than that of the control group(P<0.05).At T0 and T1,the levels of IL-6 and TNF-alpha in the observation group were lower than those in the control group(P<0.05).Conclusion Yiqi Qingre Huoxue Recipe can maintain the anti-inflammatory and inflammation-producing balance by regulating the body s immunity and reducing the over-expression of inflammatory factors,helping to reduce the hospital infection rate of stroke patients and promoting the early recovery of patients.
作者
王磊
安永辉
郭涵博
WANG Lei;AN Yonghui;GUO Hanbo(Department of Internal Medicine,Henan Provincial Construction Hospital,Zhengzhou 450000,China;Department of Traditional Chinese and Western Medicine Infection,Zhengzhou Sixth People’s Hospital,Zhengzhou 450000,China)
出处
《中国民族民间医药》
2020年第3期96-99,共4页
Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词
脑卒中
医院感染
益气清热活血方
炎症因子
Stroke
Nosocomial infection
Yiqi Qingre Huoxue Recipe
Inflammatory factors
