摘要
目的研究高血压患者血清超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、尿酸(UA)水平与颈动脉粥样硬化的相关性。方法选择2015年3月-2018年7月在本院就诊的原发性高血压患者,根据颈动脉超声结果分为合并颈动脉粥样硬化组、不合并颈动脉粥样硬化组;另取同期体检的健康者作为对照组。测定血清中hs-CRP、Hcy、UA的水平。结果合并颈动脉粥样硬化组血清hs-CRP、Hcy、UA水平均高于对照组和不合并颈动脉粥样硬化组(P<0.05);合并颈动脉粥样硬化组中软斑块患者的血清hs-CRP、Hcy、UA水平均高于硬斑块患者(P<0.05);合并颈动脉粥样硬化组中hs-CRP高水平、Hcy高水平、UA高水平患者的颈动脉内中膜厚度及斑块面积均高于hs-CRP正常水平、Hcy正常水平、UA正常水平的患者(P<0.05)。结论高血压患者的血清hs-CRP、Hcy、UA水平与颈动脉粥样硬化的病变程度密切相关。
Objective To study the correlation between serum high sensitive C reactive protein(hs-CRP),homocysteine(Hcy),uric acid(UA)levels and carotid atherosclerosis in patients with hypertension.Methods Patients with essential hypertension who were treated in our hospital from March 2015 to July 2018 were divided into group C with carotid atherosclerosis and group B without carotid atherosclerosis according to carotid ultrasound results,and healthy persons who underwent physical examination during the same period were selected as group A.The levels of hs-CRP,Hcy and UA in serum were determined.Results The serum hs-CRP,Hcy and UA levels in group C with carotid atherosclerosis were higher than those in group A and group B(P<0.05);the serum hs-CRP,Hcy and UA levels of patients with soft plaque in group C with carotid atherosclerosis were higher than those in patients with soft plaque(P<0.05);the carotid intima-media thickness and plaque area in patients with high hs-CRP,Hcy and UA levels in group C with carotid atherosclerosis were higher than those in patients with normal hs-CRP,Hcy and UA levels(P<0.05).Conclusion The levels of hs-CRP,Hcy and UA in patients with hypertension closelycorrelates are closely correlated with the degree of carotid atherosclerosis.
作者
季伟星
王鑫华
郑瑶
周兴辉
JI Wei-xing;WANG Xin-hua;ZHENG Yao;ZHOU Xing-hui(Clinical Laboratory,Taizhou Integrated Chinese and Western Medicine Hospital,Taizhou,Zhejiang 317523,China)
出处
《中国卫生检验杂志》
CAS
2020年第1期52-54,共3页
Chinese Journal of Health Laboratory Technology
基金
温岭市科技计划项目(2014C311063)
