摘要
目的探讨妊娠期高血压(HDCP)孕妇围产期外周血T淋巴细胞亚群及C-反应蛋白(CRP)水平的变化情况及其临床意义。方法选取2015年4月至2017年3月确诊的HDCP围产期孕妇132例为观察组,选取同期正常围产期孕妇100例为对照组,分析比较两组CD3^+、CD4^+、CD8^+的百分比及CRP水平;根据病情严重程度将观察组分为轻、中、重度三个亚组,比较不同病情HDCP孕妇外周血中CD3^+、CD4^+、CD8^+的百分比及CRP水平。结果观察组孕产妇T淋巴细胞亚群CD3^+、CD4^+、CD8^+百分比均高于对照组,差异均具有统计学意义(t值分别为9.23、5.79、12.05,均P<0.01);观察组CRP水平明显高于对照组(t=8.33,P<0.01);T淋巴细胞亚群CD3^+、CD4^+、CD8^+百分比随病情严重程度加重而逐渐增高,差异均具有统计学意义(F值分别为10.03、3.14、6.97,均P<0.05);CRP水平也随着患者病情加重逐渐增高(F=33.28,P<0.01)。结论妊娠期检测孕产妇外周血T淋巴细胞亚群指标与CRP有助于了解子宫胎盘的炎症反应,全面分析患者病情及并发症的发展与变化程度,对治疗方案的选择、降低母儿并发症、提高围生儿健康水平具有重要意义。
Objective To investigate the changes of peripheral blood T lymphocyte subsets and C-reactive protein(CRP) levels in women with hypertensive disorder complicating pregnancy(HDCP) and their clinical significance.Methods From April 2015 to March 2017,132 cases of HDCP perinatal women were selected as observation group,and 100 cases of normal perinatal women were selected as control group.The percentages of CD3^+,CD4^+ and CD8^+ and CRP levels were compared between two groups.According to the severity of the disease,the observed components were divided into mild subgroup,moderate subgroup and severe subgroup.The percentages of CD3^+,CD4^+ and CD8^+ and CRP levels in peripheral blood of pregnant women with different HDCP conditions were compared.Results The percentages of CD3^+,CD4^+ and CD8^+ of Tlymphocyte subsets in the observation group were higher than those in the control group,and the differences were statistically significant(t value was 9.23,5.79 and 12.05,respectively,P<0.01 for all).The level of CRP in the observation group was significantly higher than that in the control group(t=8.33,P<0.01).The percentages of CD3^+,CD4^+,CD8^+ of T lymphocyte subsets increased with the severity of the disease,and the differences were statistically significant(F value was 10.03,3.14,and 6.97,respectively,P<0.05 for all).The level of CRP also increased with the aggravation of patients’ condition(F=33.28,P<0.01).Conclusion Detection of T lymphocyte subsets and CRP in peripheral blood during pregnancy has important significance to understand the inflammatory reaction of uterus and placenta,and to comprehensively analyze the development and changes of the patient’s condition and complications.It is of great significance to the selection of treatment options,the reduction of maternal and fetal complications,and the improvement of perinatal health.
作者
张敏
江华
ZHANG Min;JIANG Hua(Department of Obstetrics and Gynecology,Affiliated Maternity Hospital of Nanjing Medical University,Jiangsu Nanjing 210004,China)
出处
《中国妇幼健康研究》
2019年第12期1511-1514,共4页
Chinese Journal of Woman and Child Health Research
关键词
妊娠期高血压疾病
围产期
T淋巴细胞亚群
C-反应蛋白
hypertensive disorder complicating pregnancy(HDCP)
perinatal period
T lymphocyte subsets
C-reactive protein(CRP)
