摘要
目的探讨前列地尔治疗冠心病心绞痛的疗效及对患者血管内皮功能的影响。方法选取2018年1月~2019年1月我院收治的68例冠心病心绞痛患者作为研究对象,按照随机数字表法分为观察组和对照组,各34例。对照组给予常规治疗,观察组在对照组基础上给予前列地尔治疗,比较两组治疗总有效率、血清超敏C反应蛋白(hs-CRP)、一氧化氮(NO)、内皮素(ET-1)以及不良反应发生率。结果观察组治疗总有效率为97.06%,高于对照组的76.47%(P<0.05);治疗后,观察组hs-CRP、ET-1低于对照组,NO高于对照组(P<0.05);两组不良反应发生率比较(P>0.05)。结论前列地尔治疗冠心病心绞痛可提升临床疗效,减少患者心绞痛发作次数,减轻患者炎症反应,提高血管内皮功能。
Objective To investigate the effect of alprostadil on angina pectoris of coronary heart disease and its effect on vascular endothelial function.Methods From January 2018 to January 2019,68 patients with angina pectoris of coronary heart disease treated in our hospital were selected as the research objects,and they were divided into observation group and control group according to the random number table method,with 34 cases each.The control group was given conventional treatment.The observation group was given alprostadil on the basis of the control group.The total effective rate,serum high-sensitivity C-reactive protein(hs-CRP),nitric oxide(NO),and endothelin(ET-1)and the incidence of adverse reactions.Results The total effective rate of treatment in the observation group was 97.06%,which was higher than 76.47%in the control group(P<0.05).After treatment,hs-CRP and ET-1 in the observation group were lower than the control group,and NO was higher than the control group(P<0.05);Comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion Alprostadil treatment of coronary heart disease and angina pectoris can improve clinical efficacy,reduce the number of angina pectoris episodes,reduce inflammation and improve vascular endothelial function.
作者
张梓宸
ZHANG Zi-chen(Department of Cardiology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
出处
《医学信息》
2020年第1期149-150,共2页
Journal of Medical Information
关键词
前列地尔
冠心病心绞痛
血管内皮功能
炎症反应
Alprostadil
Coronary heart disease angina pectoris
Vascular endothelial function
Inflammatory response
