摘要
目的:观察津力达颗粒联合地特胰岛素治疗妊娠期糖尿病的临床疗效。方法:将80例患者按就诊顺序随机分为观察组、对照组各40例。对照组每晚皮下注射地特胰岛素,0.1U/kg。观察组在对照组治疗基础上口服津力达颗粒,9g/次3次/d。2组均连续治疗1个月。比较2组血糖水平、不良妊娠结局和血脂水平。结果:总有效率观察组为92.50%,对照组为77.50%2组比较差异有统计学意义(P<0.05)。治疗后2组餐后2小时血糖及空腹血糖均明显降低,差异有统计学意义(P<0.05);胰岛β细胞功能(HCMA-β)明显升高,差异有统计学意义(P<0.05);上述指标治疗后2组比较,差异有统计学意义(P<0.05)。妊娠不良结局发生率观察组为12.50%,对照组为40.00%,2组比较差异有统计学意义(P<0.05)。甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)治疗前,2组比较差异无统计学意义(P>0.05);治疗后,TG、TC、LDL-C水平2组均降低,HDL-C水平2组均升高,差异均有统计学意义(P<0.05);上述指标治疗后2组比较,差异有统计学意义(P<0.05)。结论:津力达颗粒联合地特胰岛素可以显著提高妊娠期糖尿病患者的治疗效果,有效控制血脂和血糖水平,降低不良妊娠结局的发生率。
Objective:To observe clinical effects of Jinlida granules joined with insulin detemir in the treatment for gestational diabetes.Methods:Eighty patients were allocated to the observation group and the control group according to the visiting order,40 cases each group.The control group accepted hypodermic injection of insulin detemir,0.1 U/kg.The observation group took Jinlida granules based on insulin detemir,9 g each time,three times each day.Both groups were treated for one month consecutively.To compare the levels of blood glucose,adverse pregnancy outcome and the level of blood lipid between both groups.Results:Total effective rate of the observation group was 92.50%,higher than 77.50% of the control group,and the difference showed statistical meaning between both groups(P<0.05).After treating,2 hr postprandial plasma glucose and fasting blood glucose of both groups reduced notably,and the difference could be found(P<0.05);HOMA-β rose remarkably(P<0.05),and the difference showed statistical meaning;the difference showed statistical meaning in these indexes between both groups after treating(P<0.05).The incidence of adverse pregnancy outcome in the observation group was 12.50%,lower than 40.00% of the control group,and the difference showed statistical meaning(P <0.05).The difference showed no statistical meaning in the levels of TG,TC,HDL-C and LDL-C before treating(P>0.05);after treating,the levels of TG,TC and LDL-C in both groups reduced,and HDL-C level rose in both groups,and the difference had statistical meaning(P<0.05);the difference showed statistical meaning in these indexes between both groups after treating(P <0.05).Conclusion:Jinlida granules joined with insulin detemir in the treatment for gestational diabetes could significantly raise therapeutic effects of the patients,effectively control the levels of blood lipid and plasma glucose and reduce the incidence of adverse pregnancy outcome.
作者
李薇薇
庄娜
LI Weiwei;ZHUANG Na(Changji Hui Autonomous Prefecture People′s Hospital,ChangJi 831100,China)
出处
《西部中医药》
2019年第10期88-90,共3页
Western Journal of Traditional Chinese Medicine
基金
昌吉州科学研究与技术开发计划项目（编号2013S01-05）
关键词
糖尿病
妊娠
津力达颗粒
地特胰岛素
diabetes
gestational
Jinlida granules
insulin detemir
