摘要
目的探讨阿托伐他汀对慢性心力衰竭(CHF)患者心功能及不良反应的影响。方法选取2016年5月至2019年5月于宜春市第二人民医院诊治的CHF患者60例作为研究对象,随机分为观察组和对照组,各30例。对照组行常规抗心力衰竭治疗,观察组加用阿托伐他汀治疗,比较两组患者心功能指标、6 min步行距离(6MWD)及不良反应发生情况。结果治疗后,与对照组比较,观察组二尖瓣E峰/A峰(E/A)、左室射血分数(LVEF)、6MWD升高,左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)下降,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 CHF患者应用阿托伐他汀,可有效改善心功能,增强运动耐力,安全性较高,可用于长期治疗。
Objective To explore the effects of atorvastatin on cardiac function and adverse reactions in patients with chronic heart failure(CHF). Methods From May 2016 to May 2019, 60 patients with CHF were randomly divided into observation group and control group, with 30 cases in each group. The control group was treated with conventional anti heart failure treatment, while the observation group was additionally treated with atorvastatin. The cardiac function index, 6 min walking distance(6 MWD) and adverse reactions were compared between the 2 groups. Results After treatment, compared with control group, the mitral valve E/A, left ventricular ejection fraction(LVEF) and 6 MWD in observation group were higher, and the left ventricular end systolic diameter(LVESD) and left ventricular end diastolic diameter(LVEDD) in observation group were lower(P<0.05);There was no statistical difference in the incidence of adverse reactions between 2 groups(P>0.05). Conclusion Atorvastatin for patients with CHF can improve cardiac function, enhance exercise tolerance and have higher safety, which can be used in long-term treatment.
作者
易爱民
张丽红
YI Ai-Min;ZHANG Li-Hong(Yichun Second People’s Hospital,Yichun 336002,China)
出处
《中国药物经济学》
2019年第11期104-106,共3页
China Journal of Pharmaceutical Economics
关键词
慢性心力衰竭
阿托伐他汀
心功能
不良反应
Chronic heart failure
Atorvastatin
Cardiac function
Adverse reactions
