摘要
目的探讨重组人脑利钠肽(rh-BNP)与硝普钠联合治疗急性心力衰竭(AHF)的临床疗效。方法将2016年1月-2017年12月于我院治疗的100例AHF病人随机分为观察组与对照组,每组50例。对照组给予硝普钠等常规治疗,观察组在对照组基础上联合rh-BNP治疗。比较两组病人治疗前后心脏功能、血清炎症因子水平以及血流动力学指标改善情况,并评价临床疗效。结果治疗后观察组左室舒张末内径(LVEDD)、左室射血分数(LVEF)改善程度均优于对照组,差异均有统计学意义(P<0.05);治疗后两组血流动力学指标均改善,且观察组治疗后中心静脉压(CVP)、肺动脉收缩压(sPAP)及心率均低于对照组,心排血量(CO)高于对照组,差异均有统计学意义(P<0.05);治疗后观察组血清N末端脑钠肽前体(NT-proBNP)、超敏C-反应蛋白(hs-CRP)、白细胞介素6(IL-6)水平均显著低于对照组,差异均有统计学意义(P<0.05);观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论硝普钠联合rh-BNP治疗AHF,能显著提升病人心脏功能,改善血流动力学指标与血清炎症因子水平,提升临床治疗效果。
Objective To investigate the clinical effect of recombination brain natriuretic peptide(rh-BNP) combined with sodium nitroprusside in the treatment of acute heart failure(AHF).Methods One hundred patients with AHF treated in our hospital from January 2016 to December 2017 were randomly divided into observation group and control group,with 50 patients in each group.The patients in control group were treated with sodium nitroprusside and other routine treatment,the patients in observation group were treated with rh-BNP on the basis of control group.Cardiac function,the level of serum inflammatory factor,and the improvement of hemodynamic index before and after the treatment were compared between two groups.The comprehensive clinical efficacy was evaluated.Results The cardiac function was significantly improved in two groups after treatment,and left ventricular end-diastolic diameter and left ventricular ejection fraction in observation group were better than those in control group after treatment(P<0.05).After treatment,the hemodynamic index were significantly improved in two groups,and the central venous pressure,heart rate,and pulmonary artery systolic pressure in observation group were lower than those in control group(P<0.05),and the cardiac output was higher than that in control group.Serum N-terminal pro-brain natriuretic peptide,hypersensitive C reactive protein,interleukin-6 in observation group were significantly lower than those in control group(P<0.05).The total effective rate in observation group was higher than that in control group(P<0.05).Conclusion Sodium nitroprusside combined with rh-BNP could significantly improve cardiac function,hemodynamic index,and serum inflammatory factor,enhance clinical efficacy in patients with AHF.
作者
卢英霞
段立萍
LU Yingxia;DUAN Liping(First Hospital of Handan City,Handan 056000,Hebei,China)
出处
《中西医结合心脑血管病杂志》
2019年第22期3474-3477,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
河北省重点研发计划项目(No.162777256)
关键词
急性心力衰竭
重组人脑利钠肽
硝普钠
心功能
血流动力学指标
炎症因子
acute heart failure
recombination brain natriuretic peptide
sodium nitroprusside
cardiac function
hemodynamic index
inflammatory factor
