摘要
目的探讨立体定向放射治疗对晚期肺腺癌患者血清癌胚抗原(CEA)、糖链抗原125(CA125)、糖链抗原125(CA153)和肿瘤特异生长因子(TSGF)表达的影响。方法将烟台市烟台山区院2015年1月至2017年5月收治的92例晚期肺腺癌患者随机分为对照组(46例)和观察组(46例)。对照组:男性28例、女性18例,年龄(57.6±7.4)岁,采用紫杉醇联合顺铂化疗;观察组:男性30例、女性16例,年龄(58.2±8.1)岁,在对照组的基础上另给予立体定位放射治疗。对比2组患者的治疗效果、血清CEA、CA125、CA153和TSGF表达水平、并发症及预后。组间比较采用t检验和χ2检验,采用Kaplan-Meier生存曲线对生存率进行分析。结果治疗后,观察组的治疗有效率为37.0%(17/46),对照组为17.4%(8/46),2组之间的差异有统计学意义(χ2=4.449,P=0.035);观察组患者的血清CEA、CA125、CA153和TSGF表达水平均明显低于对照组,差异有统计学意义(t=6.987~13.575,均P=0.000);2组并发症的发生率的差异无统计学意义(χ2=0.562,P=0.337);观察组的中位生存时间为13.6个月,对照组为10.2个月,差异有统计学意义(U=126.0,P<0.01)。结论立体定向放射治疗能够促进肺腺癌的治疗效果,降低患者的血清肿瘤标志物水平,延长患者的生存时间,值得临床借鉴应用。
Objective To investigate the effects of stereotactic radiotherapy on the expression of serum carcinoembryonic antigen(CEA),glycoprotein antigen-125(CA125),glycoprotein antigen-125(CA153),and tumor specific growth factor(TSGF)in patients with advanced lung adenocarcinoma.Methods Ninety-two patients with advanced lung adenocarcinoma admitted to Yantai Yantai m ountain hospital from January 2015 to May 2017 were equally and randomly divided into a control[46 cases:28 males and 18 females with the average of(57.6±7.4)]and an observation group[46 cases:30 males and 16 females with the average of(58.2±8.1)].The control group was treated with paclitaxel and cisplatin chemotherapy.Stereotactic radiotherapy was given on the basis of the group.The therapeutic effects;serum CEA,CA125,CA153,and TSGF expression levels;complications;and prognosis of the two groups were compared.χ2 test and t test were used for the comparison among groups,and Kaplan Meier survival curve was used to analyze the survival rate.Results The effective rates were 37.0%(17/46)and 17.4%(8/46)in the observation and the control group,respectively.The difference was significant(χ2=4.449,P=0.035).The expression levels of serum CEA,CA125,CA153,and TSGF in the observation group were significantly lower than those in the control group(t=6.987-13.575,all P=0.000).No significant difference was observed in terms of complications(χ2=0.562,P=0.337).The median survival times were 13.6 and 10.2 months in the observation and the control group,respectively.The difference was significant(U=126.0,P<0.01).Conclusion Stereotactic radiography can promote lung adenocarcinoma therapy,reduce the level of serum tumor markers,and prolong the survival period of patients.Therefore,stereotactic radiography is worthy of clinical application.
作者
廖捷
王依晖
王晓东
Liao Jie;Wang Yihui;Wang Xiaodong(Department of Thoracic Surgery,Yantaishan Hospital,Yantai 264000,China;Department of Radiotherapy,Yantaishan Hospital,Yantai 264000,China)
出处
《国际放射医学核医学杂志》
2019年第5期437-441,共5页
International Journal of Radiation Medicine and Nuclear Medicine
