摘要
越来越多的研究表明,脑源性神经营养因子(BDNF,brain-derived neurotrophic factor)及其高亲和力受体TrkB在多种肿瘤,如乳腺癌、肺癌、前列腺癌、肝细胞癌等发生发展中起着非常重要的调控作用。BDNF作为上游信号分子与相应受体结合,激活下游不同信号通路,从而对肿瘤细胞的生存、转移以及侵袭等产生重要影响。本文概述了BDNF及其受体与PI3K/Akt信号通路之间的相互作用及其对肿瘤发生发展机制研究。
More and more studies have shown that brain-derived neurotrophic factor(BDNF) and its high-affinity receptor Tropomyosin receptor kinase B(TrkB) play important roles in regulating the development and progress of various tumors such as breast cancer,lung cancer,prostate cancer and hepatocellular carcinoma.As an upstream signal molecule,BDNF binds to the corresponding receptors and activates different downstream signaling pathways,and then regulate the cell survival,metastasis and invasion in tumors.This paper summarizes the interaction between BDNF/TrkB and the PI3K/Akt signaling pathway and its regulation mechanism of tumorigenesis,in order to provide a scientific basis for basic research of tumors and provide a potential target for clinical treatment.
作者
崔文
丁子麟
甄珊珊
王婷
曹文波
杨胜利
莫赛军
CUI Wen;DING Zi-lin;ZENG Shan-shan;WANG Ting;CAO Wen-bo;YANG Sheng-li;MO Sai-jun(Dept,of Basic Oncology,Basic Medical College,Zhengzhou University,Zheng/hou,Henan 450001)
出处
《玉林师范学院学报》
2019年第2期96-99,共4页
Journal of Yulin Normal University
基金
河南省高等学校重点科研项目(18A310035)
郑州大学大学生创新创业训练计划项目(2017cxcy453,2018cxcy562)
