摘要
目的探究泛昔洛韦联合胸腺肽对生殖器疱疹患者T淋巴细胞亚群和可溶性白介素2受体(sIL-2R)水平的影响。方法选择2017年10月至2018年10月盘锦市中心医院诊治的59例生殖器疱疹患者为研究对象,按照入院先后顺序将其分为观察组(28例)和对照组(31例)。观察组患者在对照组治疗基础上联合胸腺肽进行治疗,对照组患者采用泛昔洛韦进行治疗。观察比较两组患者治疗前后T淋巴细胞亚群、sIL-2R水平和各种炎症因子的变化,并就两组患者的各种症状消退时间和不良反应发生情况进行对比性分析。结果治疗前,两组患者的T淋巴细胞亚群、sIL-2R水平及各种炎症因子水平比较,其差异均无统计学意义(均P>0.05)。治疗4周后,观察组患者的CD3^+、CD4^+、CD4^+/CD8^+水平明显高于对照组患者,其CD8^+水平明显低于对照组患者,其IL-4、IL-6、TNF-α水平和sIL-2R水平均明显低于对照组患者,其差异均具有统计学意义(均P<0.05)。观察组患者的止疱时间、止痛时间和结痂时间均明显短于对照组患者(均P<0.05)。两组患者在治疗期间出现的不良反应主要是头晕、恶心和胃部不适,两组各种不良反应发生率比较,其差异均无统计学意义(均P>0.05)。结论泛昔洛韦联合胸腺肽治疗生殖器疱疹能够有效改善其T淋巴细胞亚群和sIL-2R水平,显著提高机体细胞免疫和体液免疫功能,缓解其炎症反应,临床用药安全可靠,值得在临床推广应用。
Objective To study the effects of famciclovir combined with thymosin on the levels of T lymphocyte subsets and soluble interleukin-2 receptor(sIL-2R)in patients with genital herpes.Methods 59 patients with genital herpes in our hospital from October 2017 to October 2018 were enrolled in the study.They were divided into observation group(28 cases)and control group(31 cases)according to the order of admission.The patients in the control group were treated with famciclovir,on which basis patients in the observation group were given thymosin.The changes in T lymphocyte subsets,sIL-2R levels and inflammatory factors were observed and compared between the two groups before and after treatment.The symptoms subsidence time and incidence of adverse reactions in the two groups were compared and analyzed.Results Before treatment,there were no statistically significant differences in T lymphocyte subsets,sIL-2R levels and inflammatory factors between the two groups(all P>0.05).After 4 weeks of treatment,the levels of CD3^+,CD4^+,CD4^+/CD8^+in the observation group were significantly higher than those in the control group,and the level of CD8^+,IL-4,IL-6,TNF-alpha and sIL-2R in the observation group were significantly lower than those in the control group,all with statistically significant differences(all P<0.05).The bleb-killing time,pain-killing time and scab-forming time in the observation group were significantly shorter than that in the control group(all P<0.05).The adverse reactions of the two groups during treatment were mainly dizziness,nausea and stomach discomfort,and there was no significant difference in the incidence of adverse reactions between the two groups(all P>0.05).Conclusions In the treatment of genital herpes,famciclovir combined with thymosin can effectively improve the level of T lymphocyte subsets and sIL-2R,improve the cellular immunity and humoral immune function of the body,and alleviate the inflammatory response.The clinical medication is safe and reliable,which is worthy of promotion in clinical.
作者
李丽
孙莉
李春山
LI Li;SUN Li;LI Chunshan(Department of Research and Education,Panjin Central Hospital,Panjin 124010,Liaoning,China;Department of Dermatology,Panjin Central Hospital,Panjin 124010,Liaoning,China)
出处
《中国性科学》
2019年第11期136-139,共4页
Chinese Journal of Human Sexuality
