摘要
目的 探讨阿尔茨海默病患者生活质量的影响因素。方法 选取首都医科大学良乡教学医院收治的64例阿尔茨 海默病患者及其照料者作为研究对象,采用阿尔茨海默病生活质量测评量表(QOL-AD)、日常活动能力量表(ADL)、简易 智能量表(MMSE)、临床痴呆评定量表(CDR)、Zung氏焦虑自评量表(SAS)和Zung氏抑郁自评量表(SDS)收集患者的一 般资料和临床资料,采用Zarit照料负担量表(ZBI)、家庭负担量表(FBS)评估照料者照料负担情况,应用统计学软件分析患 者生活质量及其相关影响因素。结果 64名患者QOL-AD平均(29.30±3.22)分,其中ADL得分越高的患者QOL-AD总分越 高(P<0.05),而CDR、ZBI得分越高的患者QOL-AD总分越低(P<0.05);有焦虑抑郁情绪、合并慢性疾病、伴有精神行为 异常、无配偶或非配偶照顾的患者QOL-AD明显降低(P<0.05),而MMSE、药物治疗对患者的QOL-AD评分差异无统计学 意义(P>0.05);多因素Logistic回归分析显示,ADL、ZBI、SDS、SAS、照料者角色是QOL-AD的影响因素。结论 日常生 活能力、心理状态、照料者角色和照料负担是患者生活质量的主要影响因素,可根据相应的影响因素采取综合性措施以提高 患者的生活质量。
Objective To explore the factors that influence the quality of life of patients with Alzheimer's disease(AD). Methods Sixty-four AD patients were admitted to our hospital and their caregivers were selected as the subjects of this study. The patients' general and clinical data was collected by Quality of Life-Alzheimer's Disease(QOL-AD), activity of daily living (ADL), Mini-Mental State Examination(MMSE), Clinical Dementia Rating Scale(CDR), Zung's Self-Rating Anxiety Scale (SAS)and Zung's Self-Rating Depression Scale(SDS). The caregivers' care burden was evaluated by Zarit Burden Inventory (ZBI)and Family Burden Scale(FBS). Statistical software was used to analyze these patients' quality of life and the influencing factors. Results The mean score of QOL-AD was(29.30±3.22). Patients with higher ADL scores got higher QOL-AD scores(P <0.05), but those with higher scores of CDR and ZBI got lower QOL-AD scores(P<0.05). There was a significant decrease in the QOL-AD scores of patients with anxiety, depression, complications with chronic diseases, abnormal mental behavior, and no spouse or non-spousal care(P<0.05), but MMSE and drug therapy had no significant effect on patients' QOL-AD scores(P> 0.05). Multivariate logistic regression analysis showed that ADL, ZBI, SDS, SAS and the role of caregivers were the influencing factors of QOL-AD. Conclusion The main factors that affect the patients' quality of life include self-care ability, psychological state, caregivers' relationships with patients and caregivers' burden. It is recommended that patients' life quality be improved comprehensively based on the influencing factors.
作者
苏丹
苏燕玲
吕亚辉
王健
SU Dan;SU Yanling;LV Yahui;WANG Jian(Department of Gerontology,Beijing Liang xiang Hospital of Capital Medical University,Beijing 102401,China)
出处
《空军医学杂志》
2019年第5期447-450,457,共5页
Medical Journal of Air Force
