摘要
目的:探讨维持性腹膜透析患者合并糖尿病(DM)人群中血清成纤维细胞生长因子21(fibroblast growth factor-21,FGF-21)水平的变化及意义。方法:选取2013年01月~2018年12月在上海市交通大学附属第六人民医院集团维持性腹膜透析的348例,将患者分为糖尿病组(178例)与非糖尿病组(170例),检测血清FGF-21水平,分析两组间一般情况,FGF-21水平的差异及与临床病理生理特征的关系,受试者工作特征曲线(receiver operating characteristic,ROC)分析FGF-21在糖尿病腹膜透析中心血管事件的诊断价值,Logistic回归分析FGF-21对糖尿病腹膜透析发生心衰的风险评估价值。结果:糖尿病组患者的FGF-21水平高于非糖尿病组(NDM),结果差异具有统计学意义(P<0.05),ROC曲线分析显示,FGF-21在糖尿病腹膜透析患者的曲线下面积(area under curve,AUC)为AUC为0.932(95%Cl:0.87~0.98,P<0.001),灵敏度为93.1%,特异性为83.3%。多项Logistic回归分析表明,FGF-21是糖尿病腹膜透析发生心衰的独立危险因素(P<0.05)。结论:在腹膜透析人群中,合并糖尿病发生心血管事件的概率更大,血清FGF-21对糖尿病腹膜透析患者的心血管事件发病的诊断、发病风险评估有重要意义。
Objective:To investigate the changes and significance of serum fibroblast growth factor 21(FGF-21)levels in patients with maintenance peritoneal dialysis combined with diabetes mellitus.Methods:We choose 348 cases between January 2016 and December 2016 in our hospital maintenance peritoneal dialysis patients.The patients can be divided into diabetic group(178 cases)and non-diabetic group(170 cases),detection of serum level of FGF-21,analysis of FGF-21 level differences between the two groups,and the relationship with clinical pathological physiological characteristics,the receiver-operating characteristic curve(receiver operating characteristic,ROC)analysis the FGF-21 in diagnostic value in diabetes peritoneal dialysis,Logistic regression analysis of the value of FGF-21 in the risk assessment of heart failure in diabetic peritoneal dialysis.Results:The level of FGF-21 in the diabetic group was higher than that in the non-diabetic group,the difference was statistically significant(P<0.05),ROC curve analysis showed that the area under curve(AUC)of FGF-21 in diabetic peritoneal dialysis patients was 0.932(95%Cl:0.87~0.98,P<0.001),the sensitivity was 93.1%,specificity was 83.3%.Multinomial Logistic regression analysis showed that FGF-21 was an independent risk factor for heart failure in diabetic peritoneal dialysis(P<0.05).Conclusion:In the peritoneal dialysis population serum FGF-21 on diabetes peritoneal dialysis patients with cardiovascular events diagnosis,risk assessment is of great significance.
作者
乔诚
赵黎
张海静
倪燕萍
许涛
汪年松
QIAO Cheng;ZHAO Li;ZHANG Haijing(Department of Nephrology,Shanghai Sixth Hospital Affiliated to Shanghai Jiaotong University,Shanghai,200233)
出处
《中国中西医结合肾病杂志》
2019年第9期767-771,共5页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
国家自然基金面上项目(No.81400735,81670657)
国家自然青年基金项目(No.81300560)
上海市浦江人才计划项目(No.17PJ1407700)
上海交通大学转化医学创新基金项目(No.152H2011)
上海市徐汇区重点基金项目(No.SHXH201648)
上海市综合医院中西医结合专项项目(No.ZHYY-ZXYJHZX-201608)
