摘要
针对不同血压条件下,人体胸腹腔主动脉内血流对主动脉壁产生的作用力而易造成主动脉夹层的问题,采用基于CT图像序列重建主动脉三维模型,利用流体动力学分析方法,模拟主动脉内血流环境,通过研究血压变化引起主动脉壁所受的压力、剪切力的变化以及由此引发的血流涡流对血管壁的影响,实现对人体主动脉三维模型进行有限元分析。仿真结果显示,在高血压条件下的血流对主动脉壁施加更大的压力,易于造成血流涡流,增加了主动脉内膜破裂产生夹层的概率。研究结果使得对主动脉夹层的发病机制有了更深入的认识,对帮助预防主动脉夹层病发以及降低主动脉夹层死亡率具有重要意义。
Thoracic aorta wall is impacted by blood flow and the wall stress tears the intima,resulting in aortic dissection under different blood pressure.Aiming at the problem,computational fluid dynamics was used to simulate the blood environment in the aorta model which was segmented and reconstructed through the CT images.The effect of blood pressure changes on the aortic wall pressure,wall shear stress and the effect of blood turbulence on vessel wall were studied.The simulation experiment shows that the blood flow forces greater pressure on the aortic wall under hypertension.It is more likely to tear the aorta intima due to aortic dissection.The results of the study have a deeper understanding of the pathogenesis of aortic dissection,which is of great significance for the prevention of aortic dissection and reducing of the mortality of aortic dissection.
作者
段晓杰
左瑞雪
汪剑鸣
陈庆良
DUAN Xiao-jie;ZUO Rui-xue;WANG Jian-ming;CHEN Qing-liang(Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems,Tianjin Polytechnic University,Tianjin 300387,China;School of Electronics and Information Engineering,Tianjin Polytechnic University,Tianjin 300387,China;Tianjin Chest Hospital,Tianjin 300000,China)
出处
《计算机仿真》
北大核心
2019年第9期236-239,共4页
Computer Simulation
基金
国家自然科学基金项目(61405143,61373104)
天津市应用技术及前沿技术研究计划项目(15JCQNJC01500)
关键词
计算流体动力学
主动脉
高血压
Computational fluid dynamics(CFD)
Aorta
Hypertensio
