摘要
目的 :探讨大肠癌组织中基质金属蛋白酶 2 (MMP 2 )和基质金属蛋白酶 9(MMP 9)的表达与临床病理参数之间的关系。方法 :应用免疫组织化学S P法检测 87例大肠癌组织中MMP 2和MMP 9的表达情况。结果 :87例大肠癌组织中MMP 2和MMP 9的表达阳性率分别为 56 3 %和 55 2 %。MMP 2和MMP 9在侵及肌层的阳性表达率明显低于侵及浆膜层 ,淋巴结转移阳性组高于淋巴结转移阴性组 ,差异均有显著性 (P <0 0 5)。Dukes分期中 ,C、D期中MMP 2和MMP 9的阳性表达率明显高于A、B期 (P <0 0 5) ,而与性别、年龄、肿瘤部位、组织学类型和分化程度均无关 (P >0 0 5)。结论 :MMP 2和MMP 9可能在大肠癌浸润转移过程中发挥重要作用。
Purpose To study the expressions of matrix metalloproteinase 2(MMP 2) and matrix metalloproteinase(MMP 9) in colorectal carcinoma and their relationship with clinicopathological parameters. Methods Expressions of MMP 2 and MMP 9 in 87 cases of colorectal carcinoma were detected by S P immunohistochemical method. Results The positive rates of the expression of MMP 2 and MMP 9 in 87 cases of colorectal carcinoma were 56 3% and 55 2% respectively. The positive rates of MMP 2 and MMP 9 in colorectal carcinoma invading muscular layer were lower than those invading seroral layer, and the positive rates of MMP 2 and MMP 9 in colorectal carcinoma with lymph node metastasis were higher than those without lymph node metastasis ( P <0 05). Among Dukes staging, the positive rates of MMP 2 and MMP 9 in stages of C and D were higher than those in stages of A and B ( P <0 01). Expression rates of MMP 2 and MMP 9 were not related to sex,age,location,degree of differentiation and histological type ( P >0 05). Conclusion Both MMP 2 and MMP 9 may play important roles in invasion and metastasis in colorectal carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第5期496-498,共3页
Chinese Journal of Clinical and Experimental Pathology
基金
安徽省教育厅科研基金资助项目 (No 2 0 0 1jl2 4 0 )
