摘要
背景与目的:国外多数研究发现,由于MOC-3在肺癌组织中的阳性率明显高于胸膜间皮瘤的阳性率,因此认为MOC-3对两者鉴别诊断有重要意义,但也有少数相反的报道。CD56(神经细胞粘附分子neuralcelladhesionmolecule)对小细胞肺癌的敏感性高,对非小细胞肺癌的敏感性则报道不一。本研究旨在探讨MOC-3及CD56检测在肺癌诊断中的意义。方法:采用免疫组织化学(S-P)方法对92例肺癌组织中MOC-31及CD56进行同步检测。结果:MOC-31在肺癌中的阳性率为98.9%(91/92),其中在非小细胞肺癌(non-smallcelllungcarcinomaNSCLC)中的阳性率为98.6%(72/73),在小细胞肺癌(smalcelllungcarcinoma,SCLC)中的阳性率为100%(19/19)。CD56在肺癌中的阳性表达率为30.4%(28/92),其中在NSCLC中的阳性表达率为12.3%(9/73),在SCLC中的阳性表达率为100%(19/19)。MOC-31及CD56在癌旁肺组织及正常肺组织中均未见阳性反应。结论:MOC-31是检测肺癌的一个敏感性高特异性较强抗体。而CD56仅对SCLC有敏感性。MOC-31与CD56联合检测,对诊断SCLC更有意义。
Background & Objective: The majority of research found that the positive rate of MOC 31 is higher in lung carcinoma than that in pleural mesothelioma. So MOC 31 is regarded as an important factor in differentiating diagnosis of lung carcinoma from pleural mesothelioma. But there are also few contrary reports. CD56 (neural cell adhesion molecule) is a sensitive factor in diagnosis of small cell lung carcinoma (SCLC), but the reports about its diagnostic sensitivity in non small cell lung carcinoma (NSCLC) are different. This study was conducted to investigate the significance of MOC 31 and CD56 in diagnosis of human lung carcinoma. Method: Immunohistochemical method (S P) was used to detect MOC 31 and CD56 expression in 92 cases of lung carcinoma. Result: The positive rate of MOC 31 in lung carcinoma was 98.9%(91/92),among which,98.6%(72/73)in NSCLC,100%(19/19)in SCLC; the positive expression rate of CD56 in lung carcinoma was 30.4%(28/92), among which, 12.3%(9/73) in NSCLC,100%(19/19)in SCLC. MOC 31 and CD56 expressions in adjacent lung tissue and normal lung tissue were negative. Conclusion:MOC 31 is an antibody which is highly sensitive and peculiar to lung carcinoma,whereas CD56 only showed sensitive to SCLC. Therefore, combined detemination of MOC 31 and CD56 is more useful than that of single item in diagnosing SCLC.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2002年第11期1235-1237,共3页
Chinese Journal of Cancer
