摘要
糖尿病肾病(diabetic nephropathy,DN)是慢性肾脏病变的一种重要类型,是导致终末期肾功能衰竭的常见原因。当前临床诊断主要依赖蛋白尿和微量白蛋白尿,但因其对DN的诊断缺乏敏感性及特异性,我们需要更多的生物标志物来协助诊断DN,判断病情的严重程度并进行危险分级。发现可以早期诊断并能准确判断预后的生物标志物是当前面临的难题。近几年来,关于DN发病机制各个环节标志物的研究也取得了一些进步。本文通过查阅国内外文献,简要地综述了相关生物标志物,目的为临床上更加安全合理地诊断早期DN提供一定的依据。
Diabetic nephropathy(DN) is one of the most serious complications of diabetes and one of the main causes of end-stage renal disease.The current diagnosis mainly depends on proteinuria and microalbuminuria.However,due to its lack of sensitivity and specificity in the diagnosis of DN,we need more biomarkers to diagnose DN early,Judge Yanzhongchengdu and perform risk classification.The discovery of biomarkers capable of early diagnosis and prognosis is currently a major problem.In recent years,some progress has been made in the study of biomarkers in various stages of the pathogenesis of DN.This paper reviews the relevant biomarkers by reference to domestic and foreign literature,in order to provide some basis for the safe and reasonable diagnosis of early diabetic nephropathy.
作者
钟司宇
孙亚东
谢立凯
ZHONG Si-yu;SUN Ya-dong;XIE Li-kai(Changchun University of traditional Chinese Medicine,graduate student of grade 2017,Changchun 130117,China;Department of endocrine metabolism,The people′s Hospital of Jilin Province,Corresponding author,Changchun 130021,China)
出处
《吉林医学》
CAS
2019年第9期2110-2112,共3页
Jilin Medical Journal
关键词
早期糖尿病肾病
生物标志物
研究进展
Early diabetic nephropathy
Biomarkers
The research progress
