摘要
目的探讨后天性巨结肠的临床病理特征、病理诊断和鉴别诊断。方法分析2例后天性巨结肠患者的临床特点,并进行组织病理学和免疫组化检查。结果病例1:大体:近端肠管扩张,肠壁变薄;远端肠腔狭窄,肠壁增厚。镜下:肠壁狭窄处粘膜下层神经节细胞正常,固有层平滑肌组织增生,其间神经节细胞存在。病例2:大体:近端肠管扩张,肠壁变薄。镜下:全部肠壁粘膜下层及肌间神经节细胞均存在。免疫组织化学染色神经节细胞CR、S-100、Syn、NSE(+)阳性;CD34、CD117(-)。结论后天性巨结肠相关文献报道较少,发病率低,所以误诊漏诊的几率较大。应引起病理医师的重视,以便更好的为临床诊断、治疗以及评估预后提供及时有效的依据。
Objectives To investigate the clinicopathological features,pathologic diagnosis and differential diagnosis of acquired megacolon.Methods Two patients with acquired megacolon disease were analyzed on the disease clinical characteristics,and they were subjected to the histopathological and immunohistochemical examination.Results Case 1 showed proximal intestinal dilatation,intestinal wall thinning,distal lumen stenosis,and intestinal wall thickening. Microscopically,the submucosal ganglion cells in the stricture of the intestinal wall were present,smooth muscle tissue of lamina propria obviously proliferated and ganglion cells were present.Case 2 showed proximal intestinal dilatation,intestinal wall thinning.Under microscope,all the submucosal and intermuscular ganglion cells of the intestinal wall were present. Immunocytochemical staining showed that ganglion cells were positive for CR,S-100,Syn and NSE,but negative for CD34 and CD117.Conclusion Due to low incidence rate of the disease,the probability of misdiagnosis and missed diagnosis is higher.More attention should be paid to the disease by pathologists,so as to provide timely and effective evidence for clinical diagnosis,treatment and prognosis evaluation.
作者
于虹
都吉雅
YU Hong;DU Ji-ya(Department of Pathology,the Inner Mongolia Autonomous Region People's Hospital,Huhehot 010017,China)
出处
《诊断病理学杂志》
2019年第8期493-495,F0003,共4页
Chinese Journal of Diagnostic Pathology
