摘要
目的探讨降钙素原(PCT)和C反应蛋白(CRP)与脓毒血症诊断及预后相关性。方法选取该院2016年10月至2018年9月诊治的脓毒血症患者97例,根据疾病严重程度分为感染组(n=68)和休克组(n=29),另外选取同期健康体检者97例作为对照组,于入院当日及治疗1、3、5、7d时行PCT和CRP检测,分析上述两项监测指标与病情变化的关系,以及与患者预后的相关性。结果感染组入院当日PCT、CRP水平高于对照组,差异有统计学意义(P<0.05)。休克组入院当日PCT、CRP水平高于对照组和感染组,差异有统计学意义(P<0.05)。治疗无效的患者在入院当日及治疗1、3、5、7d时血清PCT水平高于治疗有效的患者,差异有统计学意义(P<0.05)。治疗无效的患者在入院当日及治疗1、3、5、7d时CRP水平高于治疗有效的患者,差异有统计学意义,差异有统计学意义(P<0.05)。休克组病死率高于感染组(P<0.05)。PCT、CRP水平与患者预后呈明显负相关(r分别为-0.513、-0.685,P<0.05)。结论PCT和CRP在脓毒血症中诊断价值较高,对患者预后评估准确,存在相关性。
Objective To investigate diagnosis and prognosis correlation of procalcitonin and C reactive protein in patients with sepsis.Methods A total of 97 patients with sepsis in hospital were enrolled in the study from October 2016 to September 2018,who were divided into infection group(n=68)and shock group(n=29)according to the degree of severity.A total of 97 healthy persons were enrolled in the study during the same period as control group.Procalcitonin and C reactive protein were detected at the admission day,and after treatment for 1,3,5 and 7 d.The Relationship between monitoring indicators and curative effect were analyzed.The correlation between monitoring indicators and prognosis were analyzed.Results The concentrations of procalcitonin and C reactive protein in infection group were higher than those in control group at admission day(P<0.05).The concentrations of procalcitonin and C reactive protein in shock group were higher than those in control group and infection group at admission day(P<0.05).The concentrations of procalcitonin at admission day,and after treatment for 1,3,5,and 7 d in ineffective patients were higher than those in effective patients(P<0.05).C reactive protein at admission day and after treatment for 1,3,5,7 d in ineffective patients were higher than those in effective patients(P<0.05).Mortality in shock group was higher than that in infection group(P<0.05).Procalcitonin and C reactive protein were negatively correlated with patients′prognosis(r=-0.513,-0.685,P<0.05).Conclusion Procalcitonin and C reactive protein have high diagnostic value in patients with sepsis,which have accurate prognostic evaluation and correlation.
作者
赵雅霞
代娜
ZHAO Yaxia;DAI Na(Department of Clinical Laboratory,the First Hospital Affiliated toAMU,Chongqing 400038,China)
出处
《国际检验医学杂志》
CAS
2019年第15期1882-1884,1888,共4页
International Journal of Laboratory Medicine
