摘要
目的探讨黄体酮在先兆流产患者治疗中的应用价值。方法选取本院于2017年5月—2018年5月收治的148例早期先兆流产患者为观察组,采用黄体酮治疗,另选取同期健康妊娠女性148例为对照组,行常规孕期干预;比较两组治疗前、后血清人孕激素诱导阻断因子(PIBF)与孕酮水平,比较围生儿结局、妊娠期合并症情况。结果治疗后,两组产妇胆汁淤积、胎盘前置、胎膜早破等妊娠期合并症发生率及胎儿畸形、巨大儿、早产等围生儿结局发生率比较,均无统计学差异(P>0.05)。观察组治疗后血清孕酮水平显著高于对照组(P<0.05)。观察组治疗前血清PIBF水平较对照组偏低(P<0.05),而治疗后,两组均高于治疗前(P<0.05),组间治疗后比较无统计学差异(P>0.05)。结论针对先兆流产患者,采用黄体酮治疗,能改善围生儿结局,降低妊娠期并发症,临床应用价值高。
Objective To explore the value of progesterone in the treatment of threatened abortion.Methods 148 patients with early threatened abortion treated in our hospital from May 2017 to May 2018 were treated with progesterone and 148 healthy pregnant women in the same period were selected as the control group with general pregnancy intervention.The levels of post-serum human progesterone-induced blocking factor(PIBF)and progesterone were compared before and after treatment,and the perinatal outcome and complications of pregnancy were compared as well.Results After treatment,there was no significant difference between the two groups in the incidence of pregnancy complications,such as cholestasis,placenta previa and premature rupture of membranes,and the incidence of fetal malformation,macrosomia,premature delivery and other perinatal outcomes(P>0.05).The serum progesterone level in the observation group was significantly higher than that in the control group after treatment(P<0.05).The level of serum PIBF in the observation group was lower than that in the control group before treatment(P<0.05),but after treatment,it was higher in both groups than that before treatment(P<0.05),and there was no significant difference between the two groups after treatment(P>0.05).Conclusion For threatened abortion patients,progesterone therapy can improve perinatal outcome and reduce pregnancy complications,which boosts high clinical application.
作者
徐婷
XU Ting(Duchang Maternal and Child Health Hospital,Jiujiang 332600,China)
出处
《现代医院》
2019年第8期1212-1213,1217,共3页
Modern Hospitals
关键词
黄体酮
先兆流产
妊娠期并发症
围生儿结局
Progesterone
Threatened Abortion
Pregnancy Complications
Perinatal Outcome
