摘要
目的探讨至灵胶囊联合盐酸贝那普利片治疗慢性肾小球肾炎的临床疗效。方法选取2017年10月-2018年10月来上海市普陀区人民医院进行治疗的100例慢性肾小球肾炎患者为研究对象,所有患者随机分为对照组和治疗组,每组各50例。对照组患者口服盐酸贝那普利片,10 mg/次,1次/d;治疗组在对照组的基础上口服至灵胶囊,3粒/次,3次/d。2周为1个疗程,两组患者持续治疗4个疗程。观察两组的临床疗效,比较两组的血肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白量(24 h Upro)、β2微球蛋白(β2-MG)、纤溶酶原激活物抑制物-1(PAI-1)、基质金属蛋白酶-9(MMP-9)和组织纤溶酶原激活物(t-PA)水平。结果治疗后,对照组和治疗组的总有效率分别为78.00%、94.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者Scr、BUN和24 h Upro水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者Scr、BUN和24 h Upro水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者β2-MG、PAI-1、MMP-9水平显著降低,t-PA水平明显升高,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者β2-MG、PAI-1、MMP-9、t-PA水平显著优于对照组,两组比较差异有统计学意义(P<0.05)。结论至灵胶囊联合盐酸贝那普利片治疗慢性肾小球肾炎具有较好的临床疗效,可改善肾功能指标,安全性较高,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Zhiling Capsules combined with Benazepril Hydrochloride Tablets in treatment of chronic glomerulonephritis. Methods Patients(100 cases) with chronic glomerulonephritis in Shanghai Putuo District People’s Hospital from October 2017 to October 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Benazepril Hydrochloride Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Zhiling Capsules on the basis of the control group, 3 grains/time, three times daily. Two weeks was a course of treatment, and patients in two groups were treated for 4 courses. After treatment, the clinical efficacies were evaluated, and the levels of Scr, BUN, 24 h Upro,β2-MG, PAI-1, MMP-9, and t-PA in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.00% and 94.00%, respectively, and there was difference between two groups(P < 0.05). After treatment, the levels of Scr, BUN, and 24 h Upro in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the renal function indicators in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of β2-MG, PAI-1, and MMP-9 in two groups were significantly decreased, but the levels of t-PA in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the serum factor indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Zhiling Capsules combined with Benazepril Hydrochloride Tablets has clinical curative effect in treatment of chronic glomerulonephritis, can improve renal function indicators, with good safety, which has a certain clinical application value.
作者
吴昊
涂必林
WU Ha;TU Bi-lin(Department of Nephrology, Shanghai Putuo District People's Hospital, Shanghai 200060, China)
出处
《现代药物与临床》
CAS
2019年第6期1789-1792,共4页
Drugs & Clinic
关键词
至灵胶囊
盐酸贝那普利片
慢性肾小球肾炎
肾功能指标
Zhiling Capsules
Benazepril Hydrochloride Tablets
chronic glomerulonephritis
renal function indicator
