摘要
目的:探究中药复方中附子的临床应用配伍规律。方法:中国知网搜集2013-2018年的期刊文献,以"附子+临床"为主题进行高级检索,对检索结果进行筛选分类,将临床文献中含有附子的中药复方录入Excel表,建立数据库,并采用SPSS Statistics 23.0、Clementine12.0等统计软件进行数据分析。结果:频数分析中,共纳入203首方剂,涉及235味中药,单味药以制附子(128次,12.34%)、白术(89次,8.58%)、细辛(83次,8.00%)等最为常见;用药类别以补虚药(35种,628次,30.15%)、清热药(26种,116次,5.57%)、活血化瘀药(25种,149次,7.15%)居多;中药药性研究中四气以温(104种,1038次,49.83%)、平(50种,350次,16.8%)、寒(65种,337次,16.18%)较多;五味以甘(94种,1 208次,35.07%)、辛(111种,1 062次,30.83%)、苦(104种,788次,22.87%)较多;归经以归肝经(117种,737次,12.49%)的中药较多,其次是脾经(94种,1 306次,22.12%)、胃经(87种,718次,12.16%)等,共涉及12经。关联规则分析发现,新的药对组合7种。因子分析得到公因子7个。结论:附子在中药复方中应用时,采用以寒制热、以甘缓毒、甘温助阳、甘寒补阴、辛以行散、扶正祛邪等配伍方法,达到增效减毒的作用,促进临床安全用药。
Objective:Through data analysis,the purpose of this paper is to explore the clinical application compatibility of aconite in traditional Chinese medicine compound prescription.Methods:The periodical literature of 2013-2018 was searched by CNKI,and advanced retrieval was carried out with the theme of"Monkshood+clinic".The retrieval results were screened and classified.The Chinese medicine compound containing aconite in clinical literature was entered into Excel table,and the database was established.SPSS Statistics 23.0,Clementine 12.0 and other statistical software were used for data analysis.Results:In frequency analysis,203 prescriptions involving 235 Chinese medicines were included.Among the single drug statistics,aconite preparation(128 times,12.34%),Atractylodes macrocephala(89 times,8.58%)and asarum(83 times,8.00%)were the most common.In the category of medication,the drugs for tonifying deficiency(35 kinds,628 times,30.15%),clearing away heat(26 kinds,116 times,5.57%)and promoting blood circulation and removing blood stasis(25 kinds,149 times,7.15%)were the most common.In the study of the properties of traditional Chinese medicine,the four Qis are mainly"temperature(104 kinds,1038 times,49.83%),Ping(50 kinds,350 times,16.8%),cold(65 kinds,337 times,16.18%),five flavors,Gan(94 kinds,1208 times,35.07%),Xin(111 kinds,1062 times,30.83%)and bitter(104 kinds,788 times,22.87%).737 times,12.49%of the Chinese medicines are more,followed by the spleen meridian(94 kinds,1306 times,22.12%)and the stomach meridian(87 kinds,718 times,12.16%)and so on,involving 12 meridians.In the analysis of association rules,seven new drug pair combinations were found.In factor analysis,seven common factors were obtained.Conclusion:According to statistics,the compatibility methods of aconite should be adopted in the application of traditional Chinese medicine compound prescription,such as controlling Heat with cold,decreasing poisoning with herbs of sweet flavor,supporting Yang with sweet and warm herbs,cold and reinforcing Yin with sweet and cold herbs,actviting Qi with pungent herbs,strengthening the Zheng Qi to dispel Evil Qi,so as to achieve the effect of synergy and detoxification and promote clinical safe drug use.
作者
刘田园
白明
刘保松
苗明三
LIU Tianyuan;BAI Ming;LIU Baosong;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou Henan China 450046)
出处
《中医学报》
CAS
2019年第6期1343-1347,共5页
Acta Chinese Medicine
基金
国家国际合作基地项目(2016-65)
公益性行业科研专项项目(201507004-2)
河南省产学研项目(182107-000029)
关键词
附子
配伍规律
以寒制热
以甘缓毒
甘温助阳
甘寒补阴
辛以行散
扶正祛邪
Monkshood
compatibility rule
controlling Heat with cold
decreasing poisoning with herbs of sweet flavor
supporting Yang with sweet and warm herbs
cold and reinforcing Yin with sweet and cold herbs
actviting Qi with pungent herbs
strengthening the Zheng Qi to dispel Evil Qi
